Overexpression of p53 is associated with growth pattern and prognosis in advanced gastric cancer

Yuji Ichiyoshi, Hisao Oiwa, Shin Ichi Tomisaki, Yoshihisa Sakaguchi, Shinji Ohno, Yoshihiko Maehara, Keizo Sugimachi

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Background/Aims: The growth pattern of advanced gastric carcinoma, based on volumetric analysis, is closely associated with the biological characteristics of tumors, including DNA ploidy, and is an important prognostic factor. Abnormality of the p53 tumor suppressor gene plays an, important role in alteration, of cells and possibly leads to cancer development. Materials and Methods: Expression of tumor suppressor gene p53 was investigated immunohistochemically in the primary lesion of 196 patients with advanced gastric cancers, and the relationship of p53 immunopositivity with the growth pattern and prognosis was analyzed. Results: Positive p53 staining was found in 94 (48%) of the 196 primary carcinomas. Vessel invasions were more frequent and lymph node metastasis was more extensive in p53-positive tumors (p < 0.05), whereas p53 immunopositivity was not associated with depth of cancer invasion nor with the stage of cancer. In the column and mountain type tumors, characterized by vertical or penetrative growth, positive p53 staining was found in 53.8% and 52.9%, respectively in the funnel type tumor, characterized by superficially spreading growth, positive p53 staining was found in significantly lower incidence (28.9%, p < 0.05). The 5-year survival rates were 44.2% and 25.4% for patients with p53 negative and positive gastric carcinomas, respectively (p < 0.01). Multivariate analysis showed that p53 overexpression was an independent prognostic factor of patients with advanced gastric cancer. Conclusions: These findings suggest that p53 gene alteration is associated with less favorable prognosis of advanced gastric cancer, possibly by providing tumors with a potential of vertical growth into the gastric wall.

Original languageEnglish
Pages (from-to)546-553
Number of pages8
JournalHepato-gastroenterology
Volume44
Issue number14
Publication statusPublished - May 3 1997

Fingerprint

Stomach Neoplasms
Growth
Neoplasms
Stomach
Staining and Labeling
Tumor Suppressor Genes
Carcinoma
Ploidies
p53 Genes
Multivariate Analysis
Survival Rate
Lymph Nodes
Neoplasm Metastasis
DNA
Incidence

All Science Journal Classification (ASJC) codes

  • Hepatology
  • Gastroenterology

Cite this

Ichiyoshi, Y., Oiwa, H., Tomisaki, S. I., Sakaguchi, Y., Ohno, S., Maehara, Y., & Sugimachi, K. (1997). Overexpression of p53 is associated with growth pattern and prognosis in advanced gastric cancer. Hepato-gastroenterology, 44(14), 546-553.

Overexpression of p53 is associated with growth pattern and prognosis in advanced gastric cancer. / Ichiyoshi, Yuji; Oiwa, Hisao; Tomisaki, Shin Ichi; Sakaguchi, Yoshihisa; Ohno, Shinji; Maehara, Yoshihiko; Sugimachi, Keizo.

In: Hepato-gastroenterology, Vol. 44, No. 14, 03.05.1997, p. 546-553.

Research output: Contribution to journalArticle

Ichiyoshi, Y, Oiwa, H, Tomisaki, SI, Sakaguchi, Y, Ohno, S, Maehara, Y & Sugimachi, K 1997, 'Overexpression of p53 is associated with growth pattern and prognosis in advanced gastric cancer', Hepato-gastroenterology, vol. 44, no. 14, pp. 546-553.
Ichiyoshi Y, Oiwa H, Tomisaki SI, Sakaguchi Y, Ohno S, Maehara Y et al. Overexpression of p53 is associated with growth pattern and prognosis in advanced gastric cancer. Hepato-gastroenterology. 1997 May 3;44(14):546-553.
Ichiyoshi, Yuji ; Oiwa, Hisao ; Tomisaki, Shin Ichi ; Sakaguchi, Yoshihisa ; Ohno, Shinji ; Maehara, Yoshihiko ; Sugimachi, Keizo. / Overexpression of p53 is associated with growth pattern and prognosis in advanced gastric cancer. In: Hepato-gastroenterology. 1997 ; Vol. 44, No. 14. pp. 546-553.
@article{cb9570733be2411cadc82c62b05f1e3f,
title = "Overexpression of p53 is associated with growth pattern and prognosis in advanced gastric cancer",
abstract = "Background/Aims: The growth pattern of advanced gastric carcinoma, based on volumetric analysis, is closely associated with the biological characteristics of tumors, including DNA ploidy, and is an important prognostic factor. Abnormality of the p53 tumor suppressor gene plays an, important role in alteration, of cells and possibly leads to cancer development. Materials and Methods: Expression of tumor suppressor gene p53 was investigated immunohistochemically in the primary lesion of 196 patients with advanced gastric cancers, and the relationship of p53 immunopositivity with the growth pattern and prognosis was analyzed. Results: Positive p53 staining was found in 94 (48{\%}) of the 196 primary carcinomas. Vessel invasions were more frequent and lymph node metastasis was more extensive in p53-positive tumors (p < 0.05), whereas p53 immunopositivity was not associated with depth of cancer invasion nor with the stage of cancer. In the column and mountain type tumors, characterized by vertical or penetrative growth, positive p53 staining was found in 53.8{\%} and 52.9{\%}, respectively in the funnel type tumor, characterized by superficially spreading growth, positive p53 staining was found in significantly lower incidence (28.9{\%}, p < 0.05). The 5-year survival rates were 44.2{\%} and 25.4{\%} for patients with p53 negative and positive gastric carcinomas, respectively (p < 0.01). Multivariate analysis showed that p53 overexpression was an independent prognostic factor of patients with advanced gastric cancer. Conclusions: These findings suggest that p53 gene alteration is associated with less favorable prognosis of advanced gastric cancer, possibly by providing tumors with a potential of vertical growth into the gastric wall.",
author = "Yuji Ichiyoshi and Hisao Oiwa and Tomisaki, {Shin Ichi} and Yoshihisa Sakaguchi and Shinji Ohno and Yoshihiko Maehara and Keizo Sugimachi",
year = "1997",
month = "5",
day = "3",
language = "English",
volume = "44",
pages = "546--553",
journal = "Acta hepato-splenologica",
issn = "0172-6390",
publisher = "H.G.E. Update Medical Publishing Ltd.",
number = "14",

}

TY - JOUR

T1 - Overexpression of p53 is associated with growth pattern and prognosis in advanced gastric cancer

AU - Ichiyoshi, Yuji

AU - Oiwa, Hisao

AU - Tomisaki, Shin Ichi

AU - Sakaguchi, Yoshihisa

AU - Ohno, Shinji

AU - Maehara, Yoshihiko

AU - Sugimachi, Keizo

PY - 1997/5/3

Y1 - 1997/5/3

N2 - Background/Aims: The growth pattern of advanced gastric carcinoma, based on volumetric analysis, is closely associated with the biological characteristics of tumors, including DNA ploidy, and is an important prognostic factor. Abnormality of the p53 tumor suppressor gene plays an, important role in alteration, of cells and possibly leads to cancer development. Materials and Methods: Expression of tumor suppressor gene p53 was investigated immunohistochemically in the primary lesion of 196 patients with advanced gastric cancers, and the relationship of p53 immunopositivity with the growth pattern and prognosis was analyzed. Results: Positive p53 staining was found in 94 (48%) of the 196 primary carcinomas. Vessel invasions were more frequent and lymph node metastasis was more extensive in p53-positive tumors (p < 0.05), whereas p53 immunopositivity was not associated with depth of cancer invasion nor with the stage of cancer. In the column and mountain type tumors, characterized by vertical or penetrative growth, positive p53 staining was found in 53.8% and 52.9%, respectively in the funnel type tumor, characterized by superficially spreading growth, positive p53 staining was found in significantly lower incidence (28.9%, p < 0.05). The 5-year survival rates were 44.2% and 25.4% for patients with p53 negative and positive gastric carcinomas, respectively (p < 0.01). Multivariate analysis showed that p53 overexpression was an independent prognostic factor of patients with advanced gastric cancer. Conclusions: These findings suggest that p53 gene alteration is associated with less favorable prognosis of advanced gastric cancer, possibly by providing tumors with a potential of vertical growth into the gastric wall.

AB - Background/Aims: The growth pattern of advanced gastric carcinoma, based on volumetric analysis, is closely associated with the biological characteristics of tumors, including DNA ploidy, and is an important prognostic factor. Abnormality of the p53 tumor suppressor gene plays an, important role in alteration, of cells and possibly leads to cancer development. Materials and Methods: Expression of tumor suppressor gene p53 was investigated immunohistochemically in the primary lesion of 196 patients with advanced gastric cancers, and the relationship of p53 immunopositivity with the growth pattern and prognosis was analyzed. Results: Positive p53 staining was found in 94 (48%) of the 196 primary carcinomas. Vessel invasions were more frequent and lymph node metastasis was more extensive in p53-positive tumors (p < 0.05), whereas p53 immunopositivity was not associated with depth of cancer invasion nor with the stage of cancer. In the column and mountain type tumors, characterized by vertical or penetrative growth, positive p53 staining was found in 53.8% and 52.9%, respectively in the funnel type tumor, characterized by superficially spreading growth, positive p53 staining was found in significantly lower incidence (28.9%, p < 0.05). The 5-year survival rates were 44.2% and 25.4% for patients with p53 negative and positive gastric carcinomas, respectively (p < 0.01). Multivariate analysis showed that p53 overexpression was an independent prognostic factor of patients with advanced gastric cancer. Conclusions: These findings suggest that p53 gene alteration is associated with less favorable prognosis of advanced gastric cancer, possibly by providing tumors with a potential of vertical growth into the gastric wall.

UR - http://www.scopus.com/inward/record.url?scp=0030891912&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030891912&partnerID=8YFLogxK

M3 - Article

VL - 44

SP - 546

EP - 553

JO - Acta hepato-splenologica

JF - Acta hepato-splenologica

SN - 0172-6390

IS - 14

ER -