Overexpression of p53 nuclear protein in premalignant and malignant laryngeal lesions

Torahiko Nakashima, X. F. Wang, M. Masuda, A. Inokuchi, S. Komiyama

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

To investigate the role of p53 nuclear protein mutations in the initiation and progression of laryngeal carcinoma, 111 premalignant and malignant laryngeal lesions (19 specimens with hyperkeratosis and 92 with carcinoma) were studied immunohistochemically. Overexpression of p53 was observed in 8 cases (42%) of laryngeal hyperkeratosis and 44 cases (47%) of laryngeal carcinoma. However, the expression of p53 showed no relationship to patients' clinical courses. Our study confirms that p53 overexpression can be found in laryngeal carcinogenesis and is an early event but not a useful prognostic marker.

Original languageEnglish
JournalEuropean Archives of Oto-Rhino-Laryngology
Volume256
Issue numberSUPPL. 1
DOIs
Publication statusPublished - May 10 1999

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Nuclear Proteins
Carcinoma
Carcinogenesis
Mutation

All Science Journal Classification (ASJC) codes

  • Otorhinolaryngology

Cite this

Overexpression of p53 nuclear protein in premalignant and malignant laryngeal lesions. / Nakashima, Torahiko; Wang, X. F.; Masuda, M.; Inokuchi, A.; Komiyama, S.

In: European Archives of Oto-Rhino-Laryngology, Vol. 256, No. SUPPL. 1, 10.05.1999.

Research output: Contribution to journalArticle

Nakashima, Torahiko ; Wang, X. F. ; Masuda, M. ; Inokuchi, A. ; Komiyama, S. / Overexpression of p53 nuclear protein in premalignant and malignant laryngeal lesions. In: European Archives of Oto-Rhino-Laryngology. 1999 ; Vol. 256, No. SUPPL. 1.
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