Overexpression of p53 nuclear protein in premalignant and malignant laryngeal lesions

T. Nakashima; X. F. Wang; M. Masuda; A. Inokuchi; S. Komiyama

doi:10.1007/PL00014155

Overexpression of p53 nuclear protein in premalignant and malignant laryngeal lesions

T. Nakashima, X. F. Wang, M. Masuda, A. Inokuchi, S. Komiyama

Surgery

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10 Citations (Scopus)

Abstract

To investigate the role of p53 nuclear protein mutations in the initiation and progression of laryngeal carcinoma, 111 premalignant and malignant laryngeal lesions (19 specimens with hyperkeratosis and 92 with carcinoma) were studied immunohistochemically. Overexpression of p53 was observed in 8 cases (42%) of laryngeal hyperkeratosis and 44 cases (47%) of laryngeal carcinoma. However, the expression of p53 showed no relationship to patients' clinical courses. Our study confirms that p53 overexpression can be found in laryngeal carcinogenesis and is an early event but not a useful prognostic marker.

Original language	English
Pages (from-to)	S56-S59
Journal	European Archives of Oto-Rhino-Laryngology
Volume	256
Issue number	SUPPL. 1
DOIs	https://doi.org/10.1007/PL00014155
Publication status	Published - May 10 1999

All Science Journal Classification (ASJC) codes

Otorhinolaryngology

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10.1007/PL00014155

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abstract = "To investigate the role of p53 nuclear protein mutations in the initiation and progression of laryngeal carcinoma, 111 premalignant and malignant laryngeal lesions (19 specimens with hyperkeratosis and 92 with carcinoma) were studied immunohistochemically. Overexpression of p53 was observed in 8 cases (42%) of laryngeal hyperkeratosis and 44 cases (47%) of laryngeal carcinoma. However, the expression of p53 showed no relationship to patients' clinical courses. Our study confirms that p53 overexpression can be found in laryngeal carcinogenesis and is an early event but not a useful prognostic marker.",

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T1 - Overexpression of p53 nuclear protein in premalignant and malignant laryngeal lesions

AU - Nakashima, T.

AU - Wang, X. F.

AU - Masuda, M.

AU - Inokuchi, A.

AU - Komiyama, S.

PY - 1999/5/10

Y1 - 1999/5/10

N2 - To investigate the role of p53 nuclear protein mutations in the initiation and progression of laryngeal carcinoma, 111 premalignant and malignant laryngeal lesions (19 specimens with hyperkeratosis and 92 with carcinoma) were studied immunohistochemically. Overexpression of p53 was observed in 8 cases (42%) of laryngeal hyperkeratosis and 44 cases (47%) of laryngeal carcinoma. However, the expression of p53 showed no relationship to patients' clinical courses. Our study confirms that p53 overexpression can be found in laryngeal carcinogenesis and is an early event but not a useful prognostic marker.

AB - To investigate the role of p53 nuclear protein mutations in the initiation and progression of laryngeal carcinoma, 111 premalignant and malignant laryngeal lesions (19 specimens with hyperkeratosis and 92 with carcinoma) were studied immunohistochemically. Overexpression of p53 was observed in 8 cases (42%) of laryngeal hyperkeratosis and 44 cases (47%) of laryngeal carcinoma. However, the expression of p53 showed no relationship to patients' clinical courses. Our study confirms that p53 overexpression can be found in laryngeal carcinogenesis and is an early event but not a useful prognostic marker.

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IS - SUPPL. 1

ER -

Overexpression of p53 nuclear protein in premalignant and malignant laryngeal lesions

Abstract

All Science Journal Classification (ASJC) codes

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