Overexpression of phosphorylated-STAT3 and phosphorylated-Akt correlated with the invasion and metastasis of malignant melanoma

Neng Xing Lin, Chang Zheng Huang, Hou Jun Liu, Zhi Xiang Liu, Kazunori Urabe, Masutaka Furue, Ya Ting Tu

Research output: Contribution to journalArticle

Abstract

Objective: To evaluate expression of p-STAT3 and p-Akt in malignant melanoma and their relationship with invasion and metastasis of the tumor. Methods: The expression of p-STAT3 and p-Akt in 23 cases of melanocytic nevi and 41 cases of malignant melanoma using immunohistochemistry was examined, and the relationship between the expression of p-STAT3 and p-Akt in malignant melanomas and invasion and metastasis of the tumors was evaluated. Results: The expression of p-STAT3 was seen in two of 23 cases of melanocytic nevi and in 29 of 41 cases of malignant melanoma, while p-Akt was expressed in 3 of 23 cases of melanocytic nevi and 26 of 41 cases of malignant melanoma, indicating that the expression of p-STAT3 and p-Akt in melanoma was significantly higher than that in benign nevi. There was significant correlation between the expression of p-STAT3 and p-Akt in melanoma. Furthermore, the expression rates of p-STAT3 and p-Akt were significantly higher in invasive or metastatic melanomas than those in non-invasive or non-metastatic melanomas. Conclusion: p-STAT3 and p-Akt may play important roles in the pathogenesis of malignant melanoma, and their expression may correlate with the invasion and metastasis of tumors.

Original languageEnglish
Pages (from-to)679-681
Number of pages3
JournalJournal of Clinical Dermatology
Volume36
Issue number11
Publication statusPublished - Nov 1 2007
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Dermatology

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