Overexpression of phosphorylated-STAT3 and phosphorylated-ERK protein in dermatofibrosarcoma protuberans

Nengxing Lin, Kazunori Urabe, Yoichi Moroi, Uchi Hiroshi, Takeshi Nakahara, Teruki Dainichi, Hisashi Kokuba, Yating Tu, Masutaka Furue

Research output: Contribution to journalArticle

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Abstract

The overexpression of phosphorylated signal transducer and activator of transcription-3 (p-STAT3) and phosphorylated extracellular signal-regulated kinase (p-ERK) have recently been shown to play an important role in the pathogenesis of various human tumors. However, the role of these two major signal transduction pathways in dermatofibrosarcoma protuberans (DFSP) remains unknown. This study was designed to investigate the significance of p-STAT3 and p-ERK expression in DFSP. The expressions of p-STAT3 and p-ERK were analyzed by immunohistochemical staining in formalin-fixed, paraffin-embedded tissue sections of human DFSP and dermatofibroma. Ten cases were positive for p-STAT3 expression in 14 cases of DFSP, however, only 5 cases were positive in 20 cases of dermatofibroma. Eleven out of 14 cases of DFSP expressed p-ERK, but only four cases were positive in 20 cases of dermatofibroma. The expressions of p-STAT3 and p-ERK were significantly higher than those in dermatofibroma (both p < 0.01). This study suggests that the overexpression of p-STAT3 and p-ERK may play a pivotal role in the oncogenesis of DFSP.

Original languageEnglish
Pages (from-to)262-265
Number of pages4
JournalEuropean Journal of Dermatology
Volume16
Issue number3
Publication statusPublished - May 1 2006

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Dermatofibrosarcoma
STAT3 Transcription Factor
Extracellular Signal-Regulated MAP Kinases
Benign Fibrous Histiocytoma
Proteins
Paraffin
Formaldehyde
Signal Transduction
Carcinogenesis
Staining and Labeling

All Science Journal Classification (ASJC) codes

  • Dermatology

Cite this

Overexpression of phosphorylated-STAT3 and phosphorylated-ERK protein in dermatofibrosarcoma protuberans. / Lin, Nengxing; Urabe, Kazunori; Moroi, Yoichi; Hiroshi, Uchi; Nakahara, Takeshi; Dainichi, Teruki; Kokuba, Hisashi; Tu, Yating; Furue, Masutaka.

In: European Journal of Dermatology, Vol. 16, No. 3, 01.05.2006, p. 262-265.

Research output: Contribution to journalArticle

Lin, N, Urabe, K, Moroi, Y, Hiroshi, U, Nakahara, T, Dainichi, T, Kokuba, H, Tu, Y & Furue, M 2006, 'Overexpression of phosphorylated-STAT3 and phosphorylated-ERK protein in dermatofibrosarcoma protuberans', European Journal of Dermatology, vol. 16, no. 3, pp. 262-265.
Lin, Nengxing ; Urabe, Kazunori ; Moroi, Yoichi ; Hiroshi, Uchi ; Nakahara, Takeshi ; Dainichi, Teruki ; Kokuba, Hisashi ; Tu, Yating ; Furue, Masutaka. / Overexpression of phosphorylated-STAT3 and phosphorylated-ERK protein in dermatofibrosarcoma protuberans. In: European Journal of Dermatology. 2006 ; Vol. 16, No. 3. pp. 262-265.
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AU - Moroi, Yoichi

AU - Hiroshi, Uchi

AU - Nakahara, Takeshi

AU - Dainichi, Teruki

AU - Kokuba, Hisashi

AU - Tu, Yating

AU - Furue, Masutaka

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