Overexpression of SUGT1 in human colorectal cancer and its clinicopathological significance

Masaaki Iwatsuki, Koshi Mimori, Tetsuya Sato, Hiroyuki Toh, Takehiko Yokobori, Fumiaki Tanaka, Koichi Ishikawa, Hideo Baba, Masaki Mori

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3 Citations (Scopus)

Abstract

As recent technological innovations make it possible to clarify the concordant relationship between genomic alterations and aberrant gene expression during the progression of colorectal cancer (CRC), we aimed at identifying new overexpressing genes with genomic amplification on the responsible loci in CRC. The candidate gene was found using cDNA microarray and array-based comparative genomic hybridization (CGH) analysis after laser microdissection (LMD) in 132 Japanese CRC. We focused on SUGT1, which is associated with the assembling of kinetochore proteins at the metaphase of the cell cycle, with significant association between genetic alterations and expression. SUGT1 mRNA expression was evaluated in 98 CRC cases to determine the clinicopathological significance of SUGT1 expression. The mean level of SUGT1 mRNA expression in tumor tissue specimens was significantly higher than in non-tumor tissue. The high SUGT1 expression group was characterized by a significantly elevated frequency of recurrence and a significantly poorer prognosis than the low expression group. There was a significant association between poor prognosis of CRC cases and the overexpression of SUGT1 with genomic amplification of the loci concordantly. The amplification of SUGT1 might give rise to promote the transcription of the gene directly subsequent to the progression of CRC cases with worsening prognosis.

Original languageEnglish
Pages (from-to)569-575
Number of pages7
JournalInternational Journal of Oncology
Volume36
Issue number3
DOIs
Publication statusPublished - Jan 1 2010

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Colorectal Neoplasms
Oligonucleotide Array Sequence Analysis
Inventions
Genes
Kinetochores
Microdissection
Messenger RNA
Comparative Genomic Hybridization
Metaphase
Cell Cycle
Lasers
Gene Expression
Recurrence
Neoplasms
Proteins

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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Overexpression of SUGT1 in human colorectal cancer and its clinicopathological significance. / Iwatsuki, Masaaki; Mimori, Koshi; Sato, Tetsuya; Toh, Hiroyuki; Yokobori, Takehiko; Tanaka, Fumiaki; Ishikawa, Koichi; Baba, Hideo; Mori, Masaki.

In: International Journal of Oncology, Vol. 36, No. 3, 01.01.2010, p. 569-575.

Research output: Contribution to journalArticle

Iwatsuki, Masaaki ; Mimori, Koshi ; Sato, Tetsuya ; Toh, Hiroyuki ; Yokobori, Takehiko ; Tanaka, Fumiaki ; Ishikawa, Koichi ; Baba, Hideo ; Mori, Masaki. / Overexpression of SUGT1 in human colorectal cancer and its clinicopathological significance. In: International Journal of Oncology. 2010 ; Vol. 36, No. 3. pp. 569-575.
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