Oversecretion of IL-18 in haemophagocytic lymphohistiocytosis

A novel marker of disease activity

Hidetoshi Takada, Shoichi Ohga, Yumi Mizuno, Aiko Suminoe, Akinobu Matsuzaki, Kenji Ihara, Naoko Kinukawa, Koichi Ohshima, Keizo Kohno, Masashi Kurimoto, Toshiro Hara

Research output: Contribution to journalArticle

87 Citations (Scopus)

Abstract

We investigated the significance of interleukin (IL)-18 levels in the pathophysiology of haemophagocytic lymphohistiocytosis (HLH). IL-18 levels were significantly elevated in all nine patients with active HLH compared with those of healthy controls. Serial determination of IL-18 levels in three cases, showed a gradual decrease compared with those of IL-12, interferon (IFN)-γ or soluble Fas ligand (sFasL) in the course of clinical improvement, and seemed to be elevated until complete disappearance of disease activity. IL-18 and IFN-γ (CC 0.711, P = 0.018), and IFN-γ and sFasL (CC 0.849, P = 0.0049) levels were significantly correlated. On the other hand, correlation between IL-12 and IFN-γ, IL-18 and sFasL, or IL-18 and IL-12 was not observed. IL-18, IFN-γ and sFasL levels significantly correlated with disease activity such as fever and alanine transaminase (ALT) levels. IL-18 mRNA expression was enhanced in spleen, but not in peripheral blood mononuclear cells (MNC), bone marrow MNC, liver from patients of active HLH, or the tumour from a patient with lymphoma-associated haemophagocytic syndrome (LAHS). These results suggest that IL-18 may play important roles in the pathogenesis of HLH, particularly through induction of Th1 cells. IL-18 measurement may be useful for the diagnosis and for the detection of smouldering disease activity.

Original languageEnglish
Pages (from-to)182-189
Number of pages8
JournalBritish Journal of Haematology
Volume106
Issue number1
DOIs
Publication statusPublished - Aug 2 1999

Fingerprint

Hemophagocytic Lymphohistiocytosis
Interleukin-18
Fas Ligand Protein
Interferons
Interleukin-12
Th1 Cells
Alanine Transaminase
Bone Marrow Cells
Lymphoma
Blood Cells
Fever
Spleen

All Science Journal Classification (ASJC) codes

  • Hematology

Cite this

Oversecretion of IL-18 in haemophagocytic lymphohistiocytosis : A novel marker of disease activity. / Takada, Hidetoshi; Ohga, Shoichi; Mizuno, Yumi; Suminoe, Aiko; Matsuzaki, Akinobu; Ihara, Kenji; Kinukawa, Naoko; Ohshima, Koichi; Kohno, Keizo; Kurimoto, Masashi; Hara, Toshiro.

In: British Journal of Haematology, Vol. 106, No. 1, 02.08.1999, p. 182-189.

Research output: Contribution to journalArticle

Takada, H, Ohga, S, Mizuno, Y, Suminoe, A, Matsuzaki, A, Ihara, K, Kinukawa, N, Ohshima, K, Kohno, K, Kurimoto, M & Hara, T 1999, 'Oversecretion of IL-18 in haemophagocytic lymphohistiocytosis: A novel marker of disease activity', British Journal of Haematology, vol. 106, no. 1, pp. 182-189. https://doi.org/10.1046/j.1365-2141.1999.01504.x
Takada, Hidetoshi ; Ohga, Shoichi ; Mizuno, Yumi ; Suminoe, Aiko ; Matsuzaki, Akinobu ; Ihara, Kenji ; Kinukawa, Naoko ; Ohshima, Koichi ; Kohno, Keizo ; Kurimoto, Masashi ; Hara, Toshiro. / Oversecretion of IL-18 in haemophagocytic lymphohistiocytosis : A novel marker of disease activity. In: British Journal of Haematology. 1999 ; Vol. 106, No. 1. pp. 182-189.
@article{d7e5e05838fb4063af01022c38f31cbb,
title = "Oversecretion of IL-18 in haemophagocytic lymphohistiocytosis: A novel marker of disease activity",
abstract = "We investigated the significance of interleukin (IL)-18 levels in the pathophysiology of haemophagocytic lymphohistiocytosis (HLH). IL-18 levels were significantly elevated in all nine patients with active HLH compared with those of healthy controls. Serial determination of IL-18 levels in three cases, showed a gradual decrease compared with those of IL-12, interferon (IFN)-γ or soluble Fas ligand (sFasL) in the course of clinical improvement, and seemed to be elevated until complete disappearance of disease activity. IL-18 and IFN-γ (CC 0.711, P = 0.018), and IFN-γ and sFasL (CC 0.849, P = 0.0049) levels were significantly correlated. On the other hand, correlation between IL-12 and IFN-γ, IL-18 and sFasL, or IL-18 and IL-12 was not observed. IL-18, IFN-γ and sFasL levels significantly correlated with disease activity such as fever and alanine transaminase (ALT) levels. IL-18 mRNA expression was enhanced in spleen, but not in peripheral blood mononuclear cells (MNC), bone marrow MNC, liver from patients of active HLH, or the tumour from a patient with lymphoma-associated haemophagocytic syndrome (LAHS). These results suggest that IL-18 may play important roles in the pathogenesis of HLH, particularly through induction of Th1 cells. IL-18 measurement may be useful for the diagnosis and for the detection of smouldering disease activity.",
author = "Hidetoshi Takada and Shoichi Ohga and Yumi Mizuno and Aiko Suminoe and Akinobu Matsuzaki and Kenji Ihara and Naoko Kinukawa and Koichi Ohshima and Keizo Kohno and Masashi Kurimoto and Toshiro Hara",
year = "1999",
month = "8",
day = "2",
doi = "10.1046/j.1365-2141.1999.01504.x",
language = "English",
volume = "106",
pages = "182--189",
journal = "British Journal of Haematology",
issn = "0007-1048",
publisher = "Wiley-Blackwell",
number = "1",

}

TY - JOUR

T1 - Oversecretion of IL-18 in haemophagocytic lymphohistiocytosis

T2 - A novel marker of disease activity

AU - Takada, Hidetoshi

AU - Ohga, Shoichi

AU - Mizuno, Yumi

AU - Suminoe, Aiko

AU - Matsuzaki, Akinobu

AU - Ihara, Kenji

AU - Kinukawa, Naoko

AU - Ohshima, Koichi

AU - Kohno, Keizo

AU - Kurimoto, Masashi

AU - Hara, Toshiro

PY - 1999/8/2

Y1 - 1999/8/2

N2 - We investigated the significance of interleukin (IL)-18 levels in the pathophysiology of haemophagocytic lymphohistiocytosis (HLH). IL-18 levels were significantly elevated in all nine patients with active HLH compared with those of healthy controls. Serial determination of IL-18 levels in three cases, showed a gradual decrease compared with those of IL-12, interferon (IFN)-γ or soluble Fas ligand (sFasL) in the course of clinical improvement, and seemed to be elevated until complete disappearance of disease activity. IL-18 and IFN-γ (CC 0.711, P = 0.018), and IFN-γ and sFasL (CC 0.849, P = 0.0049) levels were significantly correlated. On the other hand, correlation between IL-12 and IFN-γ, IL-18 and sFasL, or IL-18 and IL-12 was not observed. IL-18, IFN-γ and sFasL levels significantly correlated with disease activity such as fever and alanine transaminase (ALT) levels. IL-18 mRNA expression was enhanced in spleen, but not in peripheral blood mononuclear cells (MNC), bone marrow MNC, liver from patients of active HLH, or the tumour from a patient with lymphoma-associated haemophagocytic syndrome (LAHS). These results suggest that IL-18 may play important roles in the pathogenesis of HLH, particularly through induction of Th1 cells. IL-18 measurement may be useful for the diagnosis and for the detection of smouldering disease activity.

AB - We investigated the significance of interleukin (IL)-18 levels in the pathophysiology of haemophagocytic lymphohistiocytosis (HLH). IL-18 levels were significantly elevated in all nine patients with active HLH compared with those of healthy controls. Serial determination of IL-18 levels in three cases, showed a gradual decrease compared with those of IL-12, interferon (IFN)-γ or soluble Fas ligand (sFasL) in the course of clinical improvement, and seemed to be elevated until complete disappearance of disease activity. IL-18 and IFN-γ (CC 0.711, P = 0.018), and IFN-γ and sFasL (CC 0.849, P = 0.0049) levels were significantly correlated. On the other hand, correlation between IL-12 and IFN-γ, IL-18 and sFasL, or IL-18 and IL-12 was not observed. IL-18, IFN-γ and sFasL levels significantly correlated with disease activity such as fever and alanine transaminase (ALT) levels. IL-18 mRNA expression was enhanced in spleen, but not in peripheral blood mononuclear cells (MNC), bone marrow MNC, liver from patients of active HLH, or the tumour from a patient with lymphoma-associated haemophagocytic syndrome (LAHS). These results suggest that IL-18 may play important roles in the pathogenesis of HLH, particularly through induction of Th1 cells. IL-18 measurement may be useful for the diagnosis and for the detection of smouldering disease activity.

UR - http://www.scopus.com/inward/record.url?scp=0032855445&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032855445&partnerID=8YFLogxK

U2 - 10.1046/j.1365-2141.1999.01504.x

DO - 10.1046/j.1365-2141.1999.01504.x

M3 - Article

VL - 106

SP - 182

EP - 189

JO - British Journal of Haematology

JF - British Journal of Haematology

SN - 0007-1048

IS - 1

ER -