OX40 costimulatory signals potentiate the memory commitment of effector CD8+ T cells

Seyed Fazlollah Mousavi, Pejman Soroosh, Takeshi Takahashi, Yasunobu Yoshikai, Hao Shen, Leo Lefrançois, Jannie Borst, Kazuo Sugamura, Naoto Ishii

    Research output: Contribution to journalArticle

    44 Citations (Scopus)

    Abstract

    A T cell costimulatory molecule, OX40, contributes to T cell expansion, survival, and cytokine production. Although several roles for OX40 in CD8 + T cell responses to tumors and viral infection have been shown, the precise function of these signals in the generation of memory CD8+ T cells remains to be elucidated. To address this, we examined the generation and maintenance of memory CD8+ T cells during infection with Listeria monocytogenes in the presence and absence of OX40 signaling. We used the expression of killer cell lectin-like receptor G1 (KLRG1), a recently reported marker, to distinguish between short-lived effector and memory precursor effector T cells (MPECs). Although OX40 was dispensable for the generation of effector T cells in general, the lack of OX40 signals significantly reduced the number and proportion of KLRG1low MPECs, and, subsequently, markedly impaired the generation of memory CD8+ T cells. Moreover, memory T cells that were generated in the absence of OX40 signals in a host animal did not show self-renewal in a second host, suggesting that OX40 is important for the maintenance of memory T cells. Additional experiments making use of an inhibitory mAb against the OX40 ligand demonstrated that OX40 signals are essential during priming, not only for the survival of KLRG1low MPECs, but also for their self-renewing ability, both of which contribute to the homeostasis of memory CD8+ T cells.

    Original languageEnglish
    Pages (from-to)5990-6001
    Number of pages12
    JournalJournal of Immunology
    Volume181
    Issue number9
    DOIs
    Publication statusPublished - Nov 1 2008

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    T-Lymphocytes
    T-Lymphoid Precursor Cells
    NK Cell Lectin-Like Receptors
    OX40 Ligand
    Maintenance
    Aptitude
    Listeria monocytogenes
    Virus Diseases
    Cell Survival
    Homeostasis
    Cytokines
    Infection
    Neoplasms

    All Science Journal Classification (ASJC) codes

    • Immunology and Allergy
    • Immunology

    Cite this

    Mousavi, S. F., Soroosh, P., Takahashi, T., Yoshikai, Y., Shen, H., Lefrançois, L., ... Ishii, N. (2008). OX40 costimulatory signals potentiate the memory commitment of effector CD8+ T cells. Journal of Immunology, 181(9), 5990-6001. https://doi.org/10.4049/jimmunol.181.9.5990

    OX40 costimulatory signals potentiate the memory commitment of effector CD8+ T cells. / Mousavi, Seyed Fazlollah; Soroosh, Pejman; Takahashi, Takeshi; Yoshikai, Yasunobu; Shen, Hao; Lefrançois, Leo; Borst, Jannie; Sugamura, Kazuo; Ishii, Naoto.

    In: Journal of Immunology, Vol. 181, No. 9, 01.11.2008, p. 5990-6001.

    Research output: Contribution to journalArticle

    Mousavi, SF, Soroosh, P, Takahashi, T, Yoshikai, Y, Shen, H, Lefrançois, L, Borst, J, Sugamura, K & Ishii, N 2008, 'OX40 costimulatory signals potentiate the memory commitment of effector CD8+ T cells', Journal of Immunology, vol. 181, no. 9, pp. 5990-6001. https://doi.org/10.4049/jimmunol.181.9.5990
    Mousavi SF, Soroosh P, Takahashi T, Yoshikai Y, Shen H, Lefrançois L et al. OX40 costimulatory signals potentiate the memory commitment of effector CD8+ T cells. Journal of Immunology. 2008 Nov 1;181(9):5990-6001. https://doi.org/10.4049/jimmunol.181.9.5990
    Mousavi, Seyed Fazlollah ; Soroosh, Pejman ; Takahashi, Takeshi ; Yoshikai, Yasunobu ; Shen, Hao ; Lefrançois, Leo ; Borst, Jannie ; Sugamura, Kazuo ; Ishii, Naoto. / OX40 costimulatory signals potentiate the memory commitment of effector CD8+ T cells. In: Journal of Immunology. 2008 ; Vol. 181, No. 9. pp. 5990-6001.
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