Oxaliplatin induces hypomyelination and reduced neuregulin 1 expression in the rat sciatic nerve

Kuniaki Tsutsumi, Yuji Yamashita, Soichiro Ushio, takehiro kawashiri, Takanori Kaname, Shunsuke Fujita, Ryozo Oishi, Nobuaki Egashira

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Oxaliplatin causes severe peripheral neuropathy. In this study, we examined hypomyelination in the peripheral nerve in oxaliplatin-induced neuropathy rat model. Gene expression of neuregulin 1 (NRG1), a myelination regulatory factor, is reduced in the dorsal root ganglion (DRG) in DNA microarray analysis. Oxaliplatin increased the g-ratio and reduced levels of myelin protein zero in sciatic nerve, suggesting the hypomyelination. Moreover, oxaliplatin reduced NRG1 mRNA levels in the DRG and decreased levels of cleaved NRG1 type III protein in the sciatic nerve. Our results indicate that oxaliplatin induces hypomyelination and reduced NRG1 expression.

Original languageEnglish
Pages (from-to)86-90
Number of pages5
JournalNeuroscience Research
Volume80
Issue number1
DOIs
Publication statusPublished - Jan 1 2014

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

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