Oxidation of Guanosine Monophosphate with O2 via a Ru-peroxo Complex in Water

Makoto Takenaka, Mitsuhiro Kikkawa, Takahiro Matsumoto, Takeshi Yatabe, Tatsuya Ando, Ki Seok Yoon, Seiji Ogo

Research output: Contribution to journalArticle

Abstract

Oxidative damage of DNA by reactive oxygen species (ROS) is responsible for aging and cancer. Although many studies of DNA damage by ROS have been conducted, there have been no reports of the oxidation of RNA components, such as guanosine monophosphate, by metal-based species in water. Here, we report the first case of oxidation of guanosine monophosphate to 8-oxoguanosine monophosphate by a metal-based oxygen bound species, derived from O2 and in water.

Original languageEnglish
Pages (from-to)3180-3184
Number of pages5
JournalChemistry - An Asian Journal
Volume13
Issue number21
DOIs
Publication statusPublished - Nov 2 2018

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Organic Chemistry

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