Oxidative stress and androgen receptor signaling in the development and progression of castration-resistant prostate cancer

Masaki Shiota, Akira Yokomizo, Seiji Naito

Research output: Contribution to journalReview articlepeer-review

73 Citations (Scopus)

Abstract

Aberrant androgen receptor (AR) signaling plays a critical role in androgen-dependent prostate cancer (PCa), as well as in castration-resistant PCa (CRPC). Oxidative stress seems to contribute to the tumorigenesis and progression of PCa, as well as the development of CRPC, via activation of AR signaling. This notion is supported by the fact that there is an aberrant or improper regulation of the redox status in these disorders. Additionally, androgen-deprivation-induced oxidative stress seems to be involved in the pathogenesis of several disorders caused by androgen-deprivation therapy (ADT), including osteoporosis, neurodegenerative disease, and cardiovascular disease. Oxidative stress can be suppressed with antioxidants or via a reduction in reactive oxygen species production. Thus, developing new therapeutic agents that reduce oxidative stress might be useful in preventing the conversion of androgen-dependent PCa into CRPC, as well as reducing the adverse effects associated with ADT. The objective of this review is to provide an overview regarding the relationship between oxidative stress and AR signaling in the context of PCa and especially CRPC. Additionally, we discuss the potential use of antioxidant therapies in the treatment of PCa.

Original languageEnglish
Pages (from-to)1320-1328
Number of pages9
JournalFree Radical Biology and Medicine
Volume51
Issue number7
DOIs
Publication statusPublished - Oct 1 2011

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Physiology (medical)

Fingerprint Dive into the research topics of 'Oxidative stress and androgen receptor signaling in the development and progression of castration-resistant prostate cancer'. Together they form a unique fingerprint.

Cite this