Oxidative stress and central cardiovascular regulation - Pathogenesis of hypertension and therapeutic aspects

Yoshitaka Hirooka, Yoji Sagara, Takuya Kishi, Kenji Sunagawa

    Research output: Contribution to journalReview articlepeer-review

    91 Citations (Scopus)

    Abstract

    Oxidative stress is a key factor in the pathogenesis of hypertension and target organ damage, beginning in the earliest stages. Extensive evidence indicates that the pivotal role of oxidative stress in the pathogenesis of hypertension is due to its effects on the vasculature in relation to the development of atherosclerotic processes. It remains unclear, however, whether oxidative stress in the brain, particularly the autonomic nuclei (including the vasomotor center), has an important role in the occurrence and maintenance of hypertension via activation of the sympathetic nervous system. The aim of the present review is to describe the contribution of oxidative stress in the brain to the neural mechanisms that underlie hypertension, and discuss evidence that brain oxidative stress is a potential therapeutic target.

    Original languageEnglish
    Pages (from-to)827-835
    Number of pages9
    JournalCirculation Journal
    Volume74
    Issue number5
    DOIs
    Publication statusPublished - 2010

    All Science Journal Classification (ASJC) codes

    • Cardiology and Cardiovascular Medicine

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