Oxytocin levels and sex differences in autism spectrum disorder with severe intellectual disabilities

Chie Aita, Yoshito Mizoguchi, Miwako Yamamoto, Yasuhisa SeguchI, Chiho Yatsuga, Taisuke Nishimura, Yoshiki Sugimoto, Daiki Takahashi, Reiko Nishihara, Takefumi Ueno, Masahiro Nakayama, Toshihide Kuroki, Hiromi Nabeta, Yoshiomi Imamura, Akira Monji

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

There were few reports of oxytocin (OXT) concentrations of autism spectrum disorder (ASD) patients with severe intellectual disabilities. We measured serum OXT concentrations in 79 hospitalized patients with severe intellectual disabilities (16–60 years old, 50 males and 29 females, 54 ASD patients) and investigated the associations between serum OXT concentration, symptom scores, sex differences, and autism spectrum disorder. There were no significant effects of diagnosis, severity of intellectual disabilities, and total score of the Japanese version of the Aberrant Behavior Checklist (ABC-J), the Childhood Autism Rating Scale-Tokyo Version (CARS-TV), and the Japanese version of the Repetitive Behavior Scale-Revised (RBS-R). However, there were sex differences in the correlations between OXT concentrations and subscale scores in the ASD group. The male ASD group (n = 39) showed negative correlations between RBS-R Self-injurious and Sameness subscale scores and serum OXT concentrations. In the female ASD group(n = 15), CARS-TV Nonverbal communication subscale scores and RBS-R Compulsive subscale scores were seen to positively correlate with serum OXT concentrations. These findings suggest that OXT functions differ in males and females with severe intellectual disabilities and that OXT partly affects autism and related to some of the repetitive behaviors and nonverbal communication, in ASD patients with severe intellectual disabilities.

Original languageEnglish
Pages (from-to)67-74
Number of pages8
JournalPsychiatry research
Volume273
DOIs
Publication statusPublished - Mar 1 2019

Fingerprint

Oxytocin
Sex Characteristics
Intellectual Disability
Autistic Disorder
Nonverbal Communication
Tokyo
Serum
Autism Spectrum Disorder
Checklist

All Science Journal Classification (ASJC) codes

  • Psychiatry and Mental health
  • Biological Psychiatry

Cite this

Aita, C., Mizoguchi, Y., Yamamoto, M., SeguchI, Y., Yatsuga, C., Nishimura, T., ... Monji, A. (2019). Oxytocin levels and sex differences in autism spectrum disorder with severe intellectual disabilities. Psychiatry research, 273, 67-74. https://doi.org/10.1016/j.psychres.2018.12.139

Oxytocin levels and sex differences in autism spectrum disorder with severe intellectual disabilities. / Aita, Chie; Mizoguchi, Yoshito; Yamamoto, Miwako; SeguchI, Yasuhisa; Yatsuga, Chiho; Nishimura, Taisuke; Sugimoto, Yoshiki; Takahashi, Daiki; Nishihara, Reiko; Ueno, Takefumi; Nakayama, Masahiro; Kuroki, Toshihide; Nabeta, Hiromi; Imamura, Yoshiomi; Monji, Akira.

In: Psychiatry research, Vol. 273, 01.03.2019, p. 67-74.

Research output: Contribution to journalArticle

Aita, C, Mizoguchi, Y, Yamamoto, M, SeguchI, Y, Yatsuga, C, Nishimura, T, Sugimoto, Y, Takahashi, D, Nishihara, R, Ueno, T, Nakayama, M, Kuroki, T, Nabeta, H, Imamura, Y & Monji, A 2019, 'Oxytocin levels and sex differences in autism spectrum disorder with severe intellectual disabilities', Psychiatry research, vol. 273, pp. 67-74. https://doi.org/10.1016/j.psychres.2018.12.139
Aita, Chie ; Mizoguchi, Yoshito ; Yamamoto, Miwako ; SeguchI, Yasuhisa ; Yatsuga, Chiho ; Nishimura, Taisuke ; Sugimoto, Yoshiki ; Takahashi, Daiki ; Nishihara, Reiko ; Ueno, Takefumi ; Nakayama, Masahiro ; Kuroki, Toshihide ; Nabeta, Hiromi ; Imamura, Yoshiomi ; Monji, Akira. / Oxytocin levels and sex differences in autism spectrum disorder with severe intellectual disabilities. In: Psychiatry research. 2019 ; Vol. 273. pp. 67-74.
@article{0ff23a29318346678ce25cf36c0a873b,
title = "Oxytocin levels and sex differences in autism spectrum disorder with severe intellectual disabilities",
abstract = "There were few reports of oxytocin (OXT) concentrations of autism spectrum disorder (ASD) patients with severe intellectual disabilities. We measured serum OXT concentrations in 79 hospitalized patients with severe intellectual disabilities (16–60 years old, 50 males and 29 females, 54 ASD patients) and investigated the associations between serum OXT concentration, symptom scores, sex differences, and autism spectrum disorder. There were no significant effects of diagnosis, severity of intellectual disabilities, and total score of the Japanese version of the Aberrant Behavior Checklist (ABC-J), the Childhood Autism Rating Scale-Tokyo Version (CARS-TV), and the Japanese version of the Repetitive Behavior Scale-Revised (RBS-R). However, there were sex differences in the correlations between OXT concentrations and subscale scores in the ASD group. The male ASD group (n = 39) showed negative correlations between RBS-R Self-injurious and Sameness subscale scores and serum OXT concentrations. In the female ASD group(n = 15), CARS-TV Nonverbal communication subscale scores and RBS-R Compulsive subscale scores were seen to positively correlate with serum OXT concentrations. These findings suggest that OXT functions differ in males and females with severe intellectual disabilities and that OXT partly affects autism and related to some of the repetitive behaviors and nonverbal communication, in ASD patients with severe intellectual disabilities.",
author = "Chie Aita and Yoshito Mizoguchi and Miwako Yamamoto and Yasuhisa SeguchI and Chiho Yatsuga and Taisuke Nishimura and Yoshiki Sugimoto and Daiki Takahashi and Reiko Nishihara and Takefumi Ueno and Masahiro Nakayama and Toshihide Kuroki and Hiromi Nabeta and Yoshiomi Imamura and Akira Monji",
year = "2019",
month = "3",
day = "1",
doi = "10.1016/j.psychres.2018.12.139",
language = "English",
volume = "273",
pages = "67--74",
journal = "Psychiatry Research",
issn = "0165-1781",
publisher = "Elsevier Ireland Ltd",

}

TY - JOUR

T1 - Oxytocin levels and sex differences in autism spectrum disorder with severe intellectual disabilities

AU - Aita, Chie

AU - Mizoguchi, Yoshito

AU - Yamamoto, Miwako

AU - SeguchI, Yasuhisa

AU - Yatsuga, Chiho

AU - Nishimura, Taisuke

AU - Sugimoto, Yoshiki

AU - Takahashi, Daiki

AU - Nishihara, Reiko

AU - Ueno, Takefumi

AU - Nakayama, Masahiro

AU - Kuroki, Toshihide

AU - Nabeta, Hiromi

AU - Imamura, Yoshiomi

AU - Monji, Akira

PY - 2019/3/1

Y1 - 2019/3/1

N2 - There were few reports of oxytocin (OXT) concentrations of autism spectrum disorder (ASD) patients with severe intellectual disabilities. We measured serum OXT concentrations in 79 hospitalized patients with severe intellectual disabilities (16–60 years old, 50 males and 29 females, 54 ASD patients) and investigated the associations between serum OXT concentration, symptom scores, sex differences, and autism spectrum disorder. There were no significant effects of diagnosis, severity of intellectual disabilities, and total score of the Japanese version of the Aberrant Behavior Checklist (ABC-J), the Childhood Autism Rating Scale-Tokyo Version (CARS-TV), and the Japanese version of the Repetitive Behavior Scale-Revised (RBS-R). However, there were sex differences in the correlations between OXT concentrations and subscale scores in the ASD group. The male ASD group (n = 39) showed negative correlations between RBS-R Self-injurious and Sameness subscale scores and serum OXT concentrations. In the female ASD group(n = 15), CARS-TV Nonverbal communication subscale scores and RBS-R Compulsive subscale scores were seen to positively correlate with serum OXT concentrations. These findings suggest that OXT functions differ in males and females with severe intellectual disabilities and that OXT partly affects autism and related to some of the repetitive behaviors and nonverbal communication, in ASD patients with severe intellectual disabilities.

AB - There were few reports of oxytocin (OXT) concentrations of autism spectrum disorder (ASD) patients with severe intellectual disabilities. We measured serum OXT concentrations in 79 hospitalized patients with severe intellectual disabilities (16–60 years old, 50 males and 29 females, 54 ASD patients) and investigated the associations between serum OXT concentration, symptom scores, sex differences, and autism spectrum disorder. There were no significant effects of diagnosis, severity of intellectual disabilities, and total score of the Japanese version of the Aberrant Behavior Checklist (ABC-J), the Childhood Autism Rating Scale-Tokyo Version (CARS-TV), and the Japanese version of the Repetitive Behavior Scale-Revised (RBS-R). However, there were sex differences in the correlations between OXT concentrations and subscale scores in the ASD group. The male ASD group (n = 39) showed negative correlations between RBS-R Self-injurious and Sameness subscale scores and serum OXT concentrations. In the female ASD group(n = 15), CARS-TV Nonverbal communication subscale scores and RBS-R Compulsive subscale scores were seen to positively correlate with serum OXT concentrations. These findings suggest that OXT functions differ in males and females with severe intellectual disabilities and that OXT partly affects autism and related to some of the repetitive behaviors and nonverbal communication, in ASD patients with severe intellectual disabilities.

UR - http://www.scopus.com/inward/record.url?scp=85059735683&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85059735683&partnerID=8YFLogxK

U2 - 10.1016/j.psychres.2018.12.139

DO - 10.1016/j.psychres.2018.12.139

M3 - Article

C2 - 30640053

AN - SCOPUS:85059735683

VL - 273

SP - 67

EP - 74

JO - Psychiatry Research

JF - Psychiatry Research

SN - 0165-1781

ER -