TY - JOUR
T1 - p-Chlorophenylalanine damages pancreatic acinar cell of the chicken
AU - Furuse, Mitsuhiro
AU - Satoh, Say
AU - Yang, Sung Ik
AU - Watanabe, Tohru
AU - Okumura, Jun Ichi
PY - 1993/11
Y1 - 1993/11
N2 - 1. Birds were injected intraperitoneally with dl-p-chlorophenylalanine (p-CP), which is an inhibitor of phenylalanine hydroxylase, or saline one day before the experiment. The weight and cell size of pancreas increased by the p-Cf treatment. 2. The application of acetylcholine (5.50 × 10-9 to 5.50 × 10-5 M) caused a dose dependent increase in amylase release from the superfused segment of pancreas, although the response significantly decreased in the pancreatic segment treated with p-CP, compared with the control.
AB - 1. Birds were injected intraperitoneally with dl-p-chlorophenylalanine (p-CP), which is an inhibitor of phenylalanine hydroxylase, or saline one day before the experiment. The weight and cell size of pancreas increased by the p-Cf treatment. 2. The application of acetylcholine (5.50 × 10-9 to 5.50 × 10-5 M) caused a dose dependent increase in amylase release from the superfused segment of pancreas, although the response significantly decreased in the pancreatic segment treated with p-CP, compared with the control.
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U2 - 10.1016/0742-8413(93)90225-A
DO - 10.1016/0742-8413(93)90225-A
M3 - Article
C2 - 7508355
AN - SCOPUS:0027763476
VL - 106
SP - 667
EP - 670
JO - Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology
JF - Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology
SN - 1367-8280
IS - 3
ER -