p-Chlorophenylalanine damages pancreatic acinar cell of the chicken

Mitsuhiro Furuse, Say Satoh, Sung Ik Yang, Tohru Watanabe, Jun Ichi Okumura

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

1. Birds were injected intraperitoneally with dl-p-chlorophenylalanine (p-CP), which is an inhibitor of phenylalanine hydroxylase, or saline one day before the experiment. The weight and cell size of pancreas increased by the p-Cf treatment. 2. The application of acetylcholine (5.50 × 10-9 to 5.50 × 10-5 M) caused a dose dependent increase in amylase release from the superfused segment of pancreas, although the response significantly decreased in the pancreatic segment treated with p-CP, compared with the control.

Original languageEnglish
Pages (from-to)667-670
Number of pages4
JournalComparative Biochemistry and Physiology. Part C: Comparative
Volume106
Issue number3
DOIs
Publication statusPublished - Nov 1993
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Immunology
  • Pharmacology

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