Paired related homoeobox 1, a new EMT inducer, is involved in metastasis and poor prognosis in colorectal cancer

Y. Takahashi, G. Sawada, J. Kurashige, R. Uchi, T. Matsumura, H. Ueo, Y. Takano, S. Akiyoshi, H. Eguchi, T. Sudo, K. Sugimachi, Y. Doki, M. Mori, K. Mimori

Research output: Contribution to journalArticlepeer-review

47 Citations (Scopus)

Abstract

Background:Paired related homoeobox 1 (PRRX1) has been identified as a new epithelial-mesenchymal transition (EMT) inducer in breast cancer. However, the function of PRRX1 in colorectal cancer (CRC) has not been elucidated.Methods:We utilised ectopic PRRX1-expressing cell lines to analyse the function of PRRX1 in CRC. The clinical significance of PRRX1 was also examined on three independent CRC case sets.Results:PRRX1 induced EMT and the stem-like phenotype in CRC cells. In contrast to studies of breast cancer, abundant expression of PRRX1 was significantly associated with metastasis and poor prognosis in CRC.Conclusion:PRRX1 is an indicator of metastasis and poor prognosis in CRC cases. Further investigation is required to uncover the signalling network regulating PRRX1.

Original languageEnglish
Pages (from-to)307-311
Number of pages5
JournalBritish journal of cancer
Volume109
Issue number2
DOIs
Publication statusPublished - Jul 23 2013

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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