Palladium-catalyzed addition reaction of polyhaloalkanes to olefins

Jiro Tsuji, Koji Sato, Hideo Nagashima

Research output: Contribution to journalArticlepeer-review

40 Citations (Scopus)

Abstract

Pd(OAc)2 combined with phosphines catalyzes homolytic cleavage of the C-Cl bond of CCl4 and CCl3CO2CH3 leading to facile addition to olefins under mild conditions. BrCCl3 also reacts with olefins to give 1,1,1-trichloro-3-bromoalkanes. The reaction is accelerated under CO atmosphere, and the presence of bases such as NaOAc or K2CO3 is essential to attain high yields of the adducts.

Original languageEnglish
Pages (from-to)393-397
Number of pages5
JournalTetrahedron
Volume41
Issue number2
DOIs
Publication statusPublished - Jan 1 1985
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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