Palladium-catalyzed benzylation of active methine compounds without additional base: Remarkable effect of 1,5-cyclooctadiene

Ryoichi Kuwano, Yutaka Kondo

Research output: Contribution to journalArticle

54 Citations (Scopus)

Abstract

(Chemical Equation Presented) The palladium complex prepared from DPPF and Cp(η3-C3H5)Pd is an effective catalyst for the alkylation of active methine compounds with benzylic carbonates under neutral conditions. The addition of 1,5-cyclooctadiene brought about remarkable improvement in the lifetime of the palladium catalyst, which led to high yields of the desired benzylation products.

Original languageEnglish
Pages (from-to)3545-3547
Number of pages3
JournalOrganic Letters
Volume6
Issue number20
DOIs
Publication statusPublished - Sep 30 2004

All Science Journal Classification (ASJC) codes

  • Molecular Medicine

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