Palladium-catalyzed C–H heteroarylation of 2,5-disubstituted imidazoles

Takaya Togo, Youhei Sohma, Yoichiro Kuninobu, Motomu Kanai

Research output: Contribution to journalArticlepeer-review

Abstract

We developed a palladium-catalyzed C–H N-heteroarylation of N-protected-2,5-disubstituted imidazoles at the C4-position using N-heteroaryl halides as a coupling partner. Intensive reaction condition screening led us to identify fluo-rinated bathophenanthroline 7 as the optimum ligand for the palladium catalyst. This reaction will enhance lead optimization of drug candidates by facilitating the synthesis of hetero-biaryl compounds containing an imidazole ring.

Original languageEnglish
Pages (from-to)196-198
Number of pages3
JournalChemical and Pharmaceutical Bulletin
Volume67
Issue number3
DOIs
Publication statusPublished - 2019

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Drug Discovery

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