Palladium-Catalyzed Decarboxylation of Benzyl Fluorobenzoates

Yusuke Makida, Yasutaka Matsumoto, Ryoichi Kuwano

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The decarboxylation of benzyl fluorobenzoates has been developed by using the palladium catalyst prepared in situ from Pd(η 3 -allyl)Cp and bulky monophosphine ligand XPhos. The catalytic reaction afforded a range of fluorinated diarylmethanes in good yields with broad functional-group compatibility. The substrates were readily synthesized by condensation of the corresponding benzoic acid with benzyl alcohol. Therefore, the transformation is formally regarded as a cross-coupling reaction between fluorine-containing benzoic acids and benzyl alcohols.

Original languageEnglish
Pages (from-to)2573-2576
Number of pages4
JournalSynlett
Volume28
Issue number19
DOIs
Publication statusPublished - Dec 1 2017

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Benzyl Alcohols
Benzyl Alcohol
Benzoic Acid
Fluorine
Benzoates
Palladium
Functional groups
Condensation
Ligands
Catalysts
Substrates
Decarboxylation

All Science Journal Classification (ASJC) codes

  • Organic Chemistry

Cite this

Palladium-Catalyzed Decarboxylation of Benzyl Fluorobenzoates. / Makida, Yusuke; Matsumoto, Yasutaka; Kuwano, Ryoichi.

In: Synlett, Vol. 28, No. 19, 01.12.2017, p. 2573-2576.

Research output: Contribution to journalArticle

Makida, Yusuke ; Matsumoto, Yasutaka ; Kuwano, Ryoichi. / Palladium-Catalyzed Decarboxylation of Benzyl Fluorobenzoates. In: Synlett. 2017 ; Vol. 28, No. 19. pp. 2573-2576.
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