Palladium-Catalyzed Decarboxylation of Benzyl Fluorobenzoates

Yusuke Makida, Yasutaka Matsumoto, Ryoichi Kuwano

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The decarboxylation of benzyl fluorobenzoates has been developed by using the palladium catalyst prepared in situ from Pd(η 3 -allyl)Cp and bulky monophosphine ligand XPhos. The catalytic reaction afforded a range of fluorinated diarylmethanes in good yields with broad functional-group compatibility. The substrates were readily synthesized by condensation of the corresponding benzoic acid with benzyl alcohol. Therefore, the transformation is formally regarded as a cross-coupling reaction between fluorine-containing benzoic acids and benzyl alcohols.

Original languageEnglish
Pages (from-to)2573-2576
Number of pages4
JournalSynlett
Volume28
Issue number19
DOIs
Publication statusPublished - Dec 1 2017

All Science Journal Classification (ASJC) codes

  • Organic Chemistry

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