Palladium-Catalyzed Secondary C(sp3)−H Arylation of 2-Alkylpyridines

Hong Liang Li, Yoichiro Kuninobu

Research output: Contribution to journalArticle

Abstract

A pyridyl group-assisted palladium-catalyzed secondary C(sp3)−H arylation protocol was developed. A substituent at the 3-position of the pyridyl group is proved to be important for promoting C−H arylation and controlling the regioselectivity. Aryl iodides can be used as coupling partners. The reaction proceeded in good to excellent yields with good functional group tolerance, even on the gram-scale. The preliminary asymmetric reaction was investigated using an L-proline derivative as a chiral ligand. (Figure presented.).

Original languageEnglish
Pages (from-to)2637-2641
Number of pages5
JournalAdvanced Synthesis and Catalysis
Volume362
Issue number13
DOIs
Publication statusPublished - Jul 16 2020

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Organic Chemistry

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