A pyridyl group-assisted palladium-catalyzed secondary C(sp3)−H arylation protocol was developed. A substituent at the 3-position of the pyridyl group is proved to be important for promoting C−H arylation and controlling the regioselectivity. Aryl iodides can be used as coupling partners. The reaction proceeded in good to excellent yields with good functional group tolerance, even on the gram-scale. The preliminary asymmetric reaction was investigated using an L-proline derivative as a chiral ligand. (Figure presented.).
All Science Journal Classification (ASJC) codes
- Organic Chemistry