Palladium-catalyzed synthesis of diaryl ketones from aldehydes and (hetero)aryl halides via C-H bond activation

Takayuki Wakaki, Takaya Togo, Daisuke Yoshidome, Yoichiro Kuninobu, Motomu Kanai

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

We developed a palladium-catalyzed C-H transformation that enabled the synthesis of ketones from aldehydes and (hetero)aryl halides. The use of picolinamide ligands was key to achieving the transformation. Heteroaryl ketones, as well as diaryl ketones, were synthesized in good to excellent yields, even in gram-scale, using this reaction. Results of density functional theory (DFT) calculations support the C-H bond activation pathway.

Original languageEnglish
Pages (from-to)3123-3128
Number of pages6
JournalACS Catalysis
Volume8
Issue number4
DOIs
Publication statusPublished - Apr 6 2018

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Palladium
Ketones
Aldehydes
Chemical activation
Density functional theory
Ligands

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Chemistry(all)

Cite this

Palladium-catalyzed synthesis of diaryl ketones from aldehydes and (hetero)aryl halides via C-H bond activation. / Wakaki, Takayuki; Togo, Takaya; Yoshidome, Daisuke; Kuninobu, Yoichiro; Kanai, Motomu.

In: ACS Catalysis, Vol. 8, No. 4, 06.04.2018, p. 3123-3128.

Research output: Contribution to journalArticle

Wakaki, Takayuki ; Togo, Takaya ; Yoshidome, Daisuke ; Kuninobu, Yoichiro ; Kanai, Motomu. / Palladium-catalyzed synthesis of diaryl ketones from aldehydes and (hetero)aryl halides via C-H bond activation. In: ACS Catalysis. 2018 ; Vol. 8, No. 4. pp. 3123-3128.
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