Palytoxin is a non-12-o-tetradecanoylphorbol-13-acetate type tumor promoter in two-stage mouse skin carcinogenesis

Hirota Fujiki, Masami Suganuma, Michie Nakayasu, Hiromi Hakii, Takahiko Horiuchi, Shozo Takayama, Takashi Sugimura

Research output: Contribution to journalArticle

93 Citations (Scopus)

Abstract

Palytoxin, which is a toxin with a molecular weight of 2681 daltons isolated from a marine coelenterate, is a potent skin irritant. However, it did not induce ornithine decarboxylase in mouse skin, or adhesion of human promyelocytic leukemia cells (HL-60). Moreover, it did not inhibit the specific binding of (3H)12-O-tetradecanoylphorbol-13-acetate (TPA) to a mouse skin particulate fraction or activate protein kinase C isolated from mouse brain in vitro. Since palytoxin showed strong irritation on mouse ear in one short-term screening test for a promoter, it was examined in a two-stage carcinogenesis experiment. The incidence of tumors in a group of mice treated with 7, 12-dimethylbenz(a)anthracene plus palytoxin was 62.5% in week 25. These tumors were identified histologically as seven papillonmas and one carcinoma. This paper reports the potent tumor-promoting activity of palytoxin, which is classified as a non-TPA-type tumor promoter.

Original languageEnglish
Pages (from-to)707-710
Number of pages4
JournalCarcinogenesis
Volume7
Issue number5
DOIs
Publication statusPublished - May 1 1986
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Cancer Research

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