Abstract
Pancreatic cancer is the fifth leading cause of cancer death and is considered to be one of the most lethal cancers in Japan.Complete surgical resection is the only curative treatment. Even if curative resection is performed, the disease usually recurs, and 5-year survival rates are less than 20%. Chemotherapy or chemoradiotherapy is selected as a standard treatment for unresectable pancreatic cancer. However, since pancreatic cancer is often resistant to chemotherapy and radiotherapy, the local control and survival rates are very low. We conducted a phase I/II clinical trial using carbon ion radiotherapy (C-ion RT) for patients with operable and locally advanced pancreatic cancer. This was delivered preop- eratively in 8 fractions over 2 weeks, was well tolerated, and resulted in excellent local control and survival rates. C-ion RT for patients with locally advanced pancreatic cancer was also well tolerated, even when concomitantly administered with the highest dose of gemcitabine (1,000 mg/m2), and likewise resulted in a good survival rate. In this chapter, we discuss current treatment methods and the results of C-ion RT for pancreatic cancer at the National Institute of Radiological Sciences.
| Original language | English |
|---|---|
| Title of host publication | Carbon-Ion Radiotherapy |
| Subtitle of host publication | Principles, Practices, and Treatment Planning |
| Publisher | Springer Japan |
| Pages | 221-228 |
| Number of pages | 8 |
| ISBN (Electronic) | 9784431544579 |
| ISBN (Print) | 9784431544562 |
| DOIs | |
| Publication status | Published - Jan 1 2014 |
Fingerprint
All Science Journal Classification (ASJC) codes
- Medicine(all)
Cite this
Pancreatic cancer. / Yamada, Shigeu; Terashima, Kohtaro; Shinoto, Makoto; Yasuda, Shigeo; Shiomi, Miho; Isozaki, Tetsuro.
Carbon-Ion Radiotherapy: Principles, Practices, and Treatment Planning. Springer Japan, 2014. p. 221-228.Research output: Chapter in Book/Report/Conference proceeding › Chapter
}
TY - CHAP
T1 - Pancreatic cancer
AU - Yamada, Shigeu
AU - Terashima, Kohtaro
AU - Shinoto, Makoto
AU - Yasuda, Shigeo
AU - Shiomi, Miho
AU - Isozaki, Tetsuro
PY - 2014/1/1
Y1 - 2014/1/1
N2 - Pancreatic cancer is the fifth leading cause of cancer death and is considered to be one of the most lethal cancers in Japan.Complete surgical resection is the only curative treatment. Even if curative resection is performed, the disease usually recurs, and 5-year survival rates are less than 20%. Chemotherapy or chemoradiotherapy is selected as a standard treatment for unresectable pancreatic cancer. However, since pancreatic cancer is often resistant to chemotherapy and radiotherapy, the local control and survival rates are very low. We conducted a phase I/II clinical trial using carbon ion radiotherapy (C-ion RT) for patients with operable and locally advanced pancreatic cancer. This was delivered preop- eratively in 8 fractions over 2 weeks, was well tolerated, and resulted in excellent local control and survival rates. C-ion RT for patients with locally advanced pancreatic cancer was also well tolerated, even when concomitantly administered with the highest dose of gemcitabine (1,000 mg/m2), and likewise resulted in a good survival rate. In this chapter, we discuss current treatment methods and the results of C-ion RT for pancreatic cancer at the National Institute of Radiological Sciences.
AB - Pancreatic cancer is the fifth leading cause of cancer death and is considered to be one of the most lethal cancers in Japan.Complete surgical resection is the only curative treatment. Even if curative resection is performed, the disease usually recurs, and 5-year survival rates are less than 20%. Chemotherapy or chemoradiotherapy is selected as a standard treatment for unresectable pancreatic cancer. However, since pancreatic cancer is often resistant to chemotherapy and radiotherapy, the local control and survival rates are very low. We conducted a phase I/II clinical trial using carbon ion radiotherapy (C-ion RT) for patients with operable and locally advanced pancreatic cancer. This was delivered preop- eratively in 8 fractions over 2 weeks, was well tolerated, and resulted in excellent local control and survival rates. C-ion RT for patients with locally advanced pancreatic cancer was also well tolerated, even when concomitantly administered with the highest dose of gemcitabine (1,000 mg/m2), and likewise resulted in a good survival rate. In this chapter, we discuss current treatment methods and the results of C-ion RT for pancreatic cancer at the National Institute of Radiological Sciences.
UR - http://www.scopus.com/inward/record.url?scp=84934268751&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84934268751&partnerID=8YFLogxK
U2 - 10.1007/978-4-431-54457-9_26
DO - 10.1007/978-4-431-54457-9_26
M3 - Chapter
AN - SCOPUS:84934268751
SN - 9784431544562
SP - 221
EP - 228
BT - Carbon-Ion Radiotherapy
PB - Springer Japan
ER -