Pannexin 3, a gap junction protein, regulates chondrocyte differentiation in part through hemichannel activity

Tsutomu Iwamoto, Mariko Ono, Makiko Arakaki, Takashi Nakamura, Aya Yamada, Satoshi Fukumoto

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Gap junctional communications play a crucial role for organogenesis including cartilage development. Pannexin 3 (Panx3) belongs to the new member of the gap junction pannexin family. However, the expression and function of Panx3 have not been cleared. Here, we demonstrate that Panx3 is expressed in cartridge, and regulates chondrocyte differentiation in vitro cell culture. Our observations indicate that Panx3 plays a crucial role for the differentiation of chondrocyte, and suggest that Panx3 is a key molecule for cartilage development.

Original languageEnglish
Title of host publicationInterface Oral Health Science 2011
PublisherSpringer Japan
Pages346-348
Number of pages3
ISBN (Electronic)9784431540700
ISBN (Print)9784431540694
DOIs
Publication statusPublished - Jan 1 2012
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Dentistry(all)

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    Iwamoto, T., Ono, M., Arakaki, M., Nakamura, T., Yamada, A., & Fukumoto, S. (2012). Pannexin 3, a gap junction protein, regulates chondrocyte differentiation in part through hemichannel activity. In Interface Oral Health Science 2011 (pp. 346-348). Springer Japan. https://doi.org/10.1007/978-4-431-54070-0_100