Parameters that help to differentiate biliary atresia from other diseases

Makoto Hayashida, Toshiharu Matsuura, Yoshiaki Kinoshita, Genshiro Esumi, Koichiro Yoshimaru, Yusuke Yanagi, Yoshiaki Takahashi, Tomoaki Taguchi

Research output: Contribution to journalArticle

Abstract

Background: The diagnosis of biliary atresia (BA) is still challenging. The aim of this study was to analyze the clinical features and parameters that contribute to a diagnosis of BA. Methods: From January 2000 to December 2013, 37 patients who underwent operative cholangiography were evaluated retrospectively. The patients were divided into two groups: a BA group, and a group with other cholestatic diseases (non-BA group). The demographic data and preoperative liver function test results were analyzed. Results: Of the 37 patients, 29 patients were confirmed to have BA. Age at operation was not significantly different between the two groups (P = 0.77). On preoperative liver function tests, only the level of γ-glutamyl transpeptidase (γ-GTP) was significantly higher in the BA group (P = 0.015). The predominant non-BA disease was inspissated bile syndrome (IBS). In the IBS patients, the jaundice was relieved after lavage of the biliary tree. Conclusion: The preoperative differentiation of cholestasis is difficult based on laboratory data and imaging. Preoperative γ-GTP may be useful for diagnosing BA, but operative cholangiography should be performed when BA is suspected and cannot be ruled out by other methods, given that the most common non-BA disease may be IBS.

Original languageEnglish
Pages (from-to)1261-1265
Number of pages5
JournalPediatrics International
Volume59
Issue number12
DOIs
Publication statusPublished - Dec 1 2017

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Biliary Atresia
Bile
Cholangiography
Liver Function Tests
gamma-Glutamyltransferase
Therapeutic Irrigation
Cholestasis
Biliary Tract
Guanosine Triphosphate
Jaundice
Demography

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health

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Parameters that help to differentiate biliary atresia from other diseases. / Hayashida, Makoto; Matsuura, Toshiharu; Kinoshita, Yoshiaki; Esumi, Genshiro; Yoshimaru, Koichiro; Yanagi, Yusuke; Takahashi, Yoshiaki; Taguchi, Tomoaki.

In: Pediatrics International, Vol. 59, No. 12, 01.12.2017, p. 1261-1265.

Research output: Contribution to journalArticle

Hayashida, Makoto ; Matsuura, Toshiharu ; Kinoshita, Yoshiaki ; Esumi, Genshiro ; Yoshimaru, Koichiro ; Yanagi, Yusuke ; Takahashi, Yoshiaki ; Taguchi, Tomoaki. / Parameters that help to differentiate biliary atresia from other diseases. In: Pediatrics International. 2017 ; Vol. 59, No. 12. pp. 1261-1265.
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abstract = "Background: The diagnosis of biliary atresia (BA) is still challenging. The aim of this study was to analyze the clinical features and parameters that contribute to a diagnosis of BA. Methods: From January 2000 to December 2013, 37 patients who underwent operative cholangiography were evaluated retrospectively. The patients were divided into two groups: a BA group, and a group with other cholestatic diseases (non-BA group). The demographic data and preoperative liver function test results were analyzed. Results: Of the 37 patients, 29 patients were confirmed to have BA. Age at operation was not significantly different between the two groups (P = 0.77). On preoperative liver function tests, only the level of γ-glutamyl transpeptidase (γ-GTP) was significantly higher in the BA group (P = 0.015). The predominant non-BA disease was inspissated bile syndrome (IBS). In the IBS patients, the jaundice was relieved after lavage of the biliary tree. Conclusion: The preoperative differentiation of cholestasis is difficult based on laboratory data and imaging. Preoperative γ-GTP may be useful for diagnosing BA, but operative cholangiography should be performed when BA is suspected and cannot be ruled out by other methods, given that the most common non-BA disease may be IBS.",
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AU - Yoshimaru, Koichiro

AU - Yanagi, Yusuke

AU - Takahashi, Yoshiaki

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