Pareto analysis for gene filtering in microarray experiments

G. Fleury, A. Hero, Shigeo Yoshida, T. Carter, C. Barlow, A. Swaroop

Research output: Contribution to journalConference article

16 Citations (Scopus)

Abstract

We introduce a method for detecting strongly monotone evolutionary trends of gene expression from a temporal sequence of microarray data. In this method we perform gene filtering via multi-objective optimization to reveal genes which have the properties of: strong monotonic increase, high end-to-end slope and low slope deviation. Both a global Pareto optimization and a pair-wise local Pareto optimization are investigated. This gene filtering method is illustrated on mouse retinal genes acquired at different points over the lifetimes of a population of mice.

Original languageEnglish
Article number7072128
JournalEuropean Signal Processing Conference
Volume2002-March
Publication statusPublished - Mar 27 2002
Event11th European Signal Processing Conference, EUSIPCO 2002 - Toulouse, France
Duration: Sep 3 2002Sep 6 2002

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Microarrays
Genes
Experiments
Multiobjective optimization
Gene expression

All Science Journal Classification (ASJC) codes

  • Signal Processing
  • Electrical and Electronic Engineering

Cite this

Fleury, G., Hero, A., Yoshida, S., Carter, T., Barlow, C., & Swaroop, A. (2002). Pareto analysis for gene filtering in microarray experiments. European Signal Processing Conference, 2002-March, [7072128].

Pareto analysis for gene filtering in microarray experiments. / Fleury, G.; Hero, A.; Yoshida, Shigeo; Carter, T.; Barlow, C.; Swaroop, A.

In: European Signal Processing Conference, Vol. 2002-March, 7072128, 27.03.2002.

Research output: Contribution to journalConference article

Fleury, G, Hero, A, Yoshida, S, Carter, T, Barlow, C & Swaroop, A 2002, 'Pareto analysis for gene filtering in microarray experiments', European Signal Processing Conference, vol. 2002-March, 7072128.
Fleury G, Hero A, Yoshida S, Carter T, Barlow C, Swaroop A. Pareto analysis for gene filtering in microarray experiments. European Signal Processing Conference. 2002 Mar 27;2002-March. 7072128.
Fleury, G. ; Hero, A. ; Yoshida, Shigeo ; Carter, T. ; Barlow, C. ; Swaroop, A. / Pareto analysis for gene filtering in microarray experiments. In: European Signal Processing Conference. 2002 ; Vol. 2002-March.
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