Parotid gland carcinoma: 32 years' experience from a single institute

T. Nakano, R. Yasumatsu, R. Kogo, K. Hashimoto, K. Asai, S. Ohga, H. Yamamoto, T. Nakashima, T. Nakagawa

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background Parotid gland carcinoma is a rare and complicated histopathological classification. Therefore, assembling a sufficient number of cases with long-term outcomes in a single institute can present a challenge.Method The medical records of 108 parotid gland carcinoma patients who were treated at Kyushu University Hospital, Fukuoka, Japan, between 1983 and 2014 were reviewed. The survival outcomes were analysed according to clinicopathological findings.Results Forty-six patients had low clinical stage tumours (I-II), and 62 patients had high clinical stage tumours (III-IV). Fifty-two, 10 and 46 patients had low-, intermediate-and high-grade tumours, respectively. Twenty-seven of 65 cases had positive surgical margins. In high clinical stage and intermediate-to high-grade tumours, adjuvant radiation therapy was correlated with local recurrence-free survival (p = 0.0244). Intermediate-to high-grade tumours and positive surgical margins were significantly associated with disease-specific survival in multivariate analysis (p = 0.0002 and p = 0.0058).Conclusion The results of this study show that adjuvant radiation therapy is useful for improved local control in patients with high clinical stage and intermediate-to high-grade tumours.

Original languageEnglish
Pages (from-to)604-609
Number of pages6
JournalJournal of Laryngology and Otology
Volume133
Issue number7
DOIs
Publication statusPublished - Jul 1 2019

Fingerprint

Parotid Gland
Carcinoma
Neoplasms
Survival
Radiotherapy
Medical Records
Japan
Multivariate Analysis
Recurrence

All Science Journal Classification (ASJC) codes

  • Otorhinolaryngology

Cite this

Parotid gland carcinoma : 32 years' experience from a single institute. / Nakano, T.; Yasumatsu, R.; Kogo, R.; Hashimoto, K.; Asai, K.; Ohga, S.; Yamamoto, H.; Nakashima, T.; Nakagawa, T.

In: Journal of Laryngology and Otology, Vol. 133, No. 7, 01.07.2019, p. 604-609.

Research output: Contribution to journalArticle

Nakano, T. ; Yasumatsu, R. ; Kogo, R. ; Hashimoto, K. ; Asai, K. ; Ohga, S. ; Yamamoto, H. ; Nakashima, T. ; Nakagawa, T. / Parotid gland carcinoma : 32 years' experience from a single institute. In: Journal of Laryngology and Otology. 2019 ; Vol. 133, No. 7. pp. 604-609.
@article{fc65cadd2cd44d4d8e3351a287248775,
title = "Parotid gland carcinoma: 32 years' experience from a single institute",
abstract = "Background Parotid gland carcinoma is a rare and complicated histopathological classification. Therefore, assembling a sufficient number of cases with long-term outcomes in a single institute can present a challenge.Method The medical records of 108 parotid gland carcinoma patients who were treated at Kyushu University Hospital, Fukuoka, Japan, between 1983 and 2014 were reviewed. The survival outcomes were analysed according to clinicopathological findings.Results Forty-six patients had low clinical stage tumours (I-II), and 62 patients had high clinical stage tumours (III-IV). Fifty-two, 10 and 46 patients had low-, intermediate-and high-grade tumours, respectively. Twenty-seven of 65 cases had positive surgical margins. In high clinical stage and intermediate-to high-grade tumours, adjuvant radiation therapy was correlated with local recurrence-free survival (p = 0.0244). Intermediate-to high-grade tumours and positive surgical margins were significantly associated with disease-specific survival in multivariate analysis (p = 0.0002 and p = 0.0058).Conclusion The results of this study show that adjuvant radiation therapy is useful for improved local control in patients with high clinical stage and intermediate-to high-grade tumours.",
author = "T. Nakano and R. Yasumatsu and R. Kogo and K. Hashimoto and K. Asai and S. Ohga and H. Yamamoto and T. Nakashima and T. Nakagawa",
year = "2019",
month = "7",
day = "1",
doi = "10.1017/S0022215119001130",
language = "English",
volume = "133",
pages = "604--609",
journal = "Journal of Laryngology and Otology",
issn = "0022-2151",
publisher = "Cambridge University Press",
number = "7",

}

TY - JOUR

T1 - Parotid gland carcinoma

T2 - 32 years' experience from a single institute

AU - Nakano, T.

AU - Yasumatsu, R.

AU - Kogo, R.

AU - Hashimoto, K.

AU - Asai, K.

AU - Ohga, S.

AU - Yamamoto, H.

AU - Nakashima, T.

AU - Nakagawa, T.

PY - 2019/7/1

Y1 - 2019/7/1

N2 - Background Parotid gland carcinoma is a rare and complicated histopathological classification. Therefore, assembling a sufficient number of cases with long-term outcomes in a single institute can present a challenge.Method The medical records of 108 parotid gland carcinoma patients who were treated at Kyushu University Hospital, Fukuoka, Japan, between 1983 and 2014 were reviewed. The survival outcomes were analysed according to clinicopathological findings.Results Forty-six patients had low clinical stage tumours (I-II), and 62 patients had high clinical stage tumours (III-IV). Fifty-two, 10 and 46 patients had low-, intermediate-and high-grade tumours, respectively. Twenty-seven of 65 cases had positive surgical margins. In high clinical stage and intermediate-to high-grade tumours, adjuvant radiation therapy was correlated with local recurrence-free survival (p = 0.0244). Intermediate-to high-grade tumours and positive surgical margins were significantly associated with disease-specific survival in multivariate analysis (p = 0.0002 and p = 0.0058).Conclusion The results of this study show that adjuvant radiation therapy is useful for improved local control in patients with high clinical stage and intermediate-to high-grade tumours.

AB - Background Parotid gland carcinoma is a rare and complicated histopathological classification. Therefore, assembling a sufficient number of cases with long-term outcomes in a single institute can present a challenge.Method The medical records of 108 parotid gland carcinoma patients who were treated at Kyushu University Hospital, Fukuoka, Japan, between 1983 and 2014 were reviewed. The survival outcomes were analysed according to clinicopathological findings.Results Forty-six patients had low clinical stage tumours (I-II), and 62 patients had high clinical stage tumours (III-IV). Fifty-two, 10 and 46 patients had low-, intermediate-and high-grade tumours, respectively. Twenty-seven of 65 cases had positive surgical margins. In high clinical stage and intermediate-to high-grade tumours, adjuvant radiation therapy was correlated with local recurrence-free survival (p = 0.0244). Intermediate-to high-grade tumours and positive surgical margins were significantly associated with disease-specific survival in multivariate analysis (p = 0.0002 and p = 0.0058).Conclusion The results of this study show that adjuvant radiation therapy is useful for improved local control in patients with high clinical stage and intermediate-to high-grade tumours.

UR - http://www.scopus.com/inward/record.url?scp=85066934488&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85066934488&partnerID=8YFLogxK

U2 - 10.1017/S0022215119001130

DO - 10.1017/S0022215119001130

M3 - Article

C2 - 31169091

AN - SCOPUS:85066934488

VL - 133

SP - 604

EP - 609

JO - Journal of Laryngology and Otology

JF - Journal of Laryngology and Otology

SN - 0022-2151

IS - 7

ER -