Partial correlation coefficient between distance matrices as a new indicator of protein-protein interactions

Tetsuya Sato, Yoshihiro Yamanishi, Katsuhisa Horimoto, Minoru Kanehisa, Hiroyuki Toh

    Research output: Contribution to journalArticle

    26 Citations (Scopus)

    Abstract

    Motivation: The computational prediction of protein-protein interactions is currently a major issue in bioinformatics. Recently, a variety of co-evolution-based methods have been investigated toward this goal. In this study, we introduced a partial correlation coefficient as a new measure for the degree of co-evolution between proteins, and proposed its use to predict protein-protein interactions. Results: The accuracy of the prediction by the proposed method was compared with those of the original mirror tree method and the projection method previously developed by our group. We found that the partial correlation coefficient effectively reduces the number of false positives, as compared with other methods, although the number of false negatives increased in the prediction by the partial correlation coefficient.

    Original languageEnglish
    Pages (from-to)2488-2492
    Number of pages5
    JournalBioinformatics
    Volume22
    Issue number20
    DOIs
    Publication statusPublished - Oct 1 2006

    Fingerprint

    Partial Correlation
    Distance Matrix
    Protein-protein Interaction
    Correlation coefficient
    Proteins
    Coevolution
    Prediction
    Projection Method
    False Positive
    Bioinformatics
    Mirror
    Computational Biology
    Protein
    Mirrors
    Predict

    All Science Journal Classification (ASJC) codes

    • Statistics and Probability
    • Biochemistry
    • Molecular Biology
    • Computer Science Applications
    • Computational Theory and Mathematics
    • Computational Mathematics

    Cite this

    Partial correlation coefficient between distance matrices as a new indicator of protein-protein interactions. / Sato, Tetsuya; Yamanishi, Yoshihiro; Horimoto, Katsuhisa; Kanehisa, Minoru; Toh, Hiroyuki.

    In: Bioinformatics, Vol. 22, No. 20, 01.10.2006, p. 2488-2492.

    Research output: Contribution to journalArticle

    Sato, Tetsuya ; Yamanishi, Yoshihiro ; Horimoto, Katsuhisa ; Kanehisa, Minoru ; Toh, Hiroyuki. / Partial correlation coefficient between distance matrices as a new indicator of protein-protein interactions. In: Bioinformatics. 2006 ; Vol. 22, No. 20. pp. 2488-2492.
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