Partial hepatectomy alters sensitivity of rat hepatocytes to 5-fluorouracil

Yoshihiko Maehara; Hideaki Anai; Ryuichiro Tamada; Keizo Sugimachi

doi:10.1016/0304-3835(86)90142-4

Partial hepatectomy alters sensitivity of rat hepatocytes to 5-fluorouracil

Yoshihiko Maehara, Hideaki Anai, Ryuichiro Tamada, Keizo Sugimachi

Surgery

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Abstract

The sensitivity to 5-fluorouracil (5-FU) and the metabolism of 5-FU in the regenerating rat liver were investigated in vitro. Determination of cell viability using the succinate dehydrogenase inhibition test showed that the hepatocytes of the partially hepatectomized liver were more sensitive to 5-FU, compared to findings in the case of normal liver. The activities of 5-FU phosphorylation of the 3 pathways were higher in the regenerating than in the intact liver and the peak increase was seen 36 h after partial hepatectomy. The activity of 5-FU degradation decreased to about 30% at 36 h and then gradually increased reaching the normal range at 72 h after partial hepatectomy. These results suggest that the metabolic changes of 5-FU may be one of the causes for increased 5-FU susceptibility in the regenerating liver.

Original language	English
Pages (from-to)	227-233
Number of pages	7
Journal	Cancer Letters
Volume	31
Issue number	3
DOIs	https://doi.org/10.1016/0304-3835(86)90142-4
Publication status	Published - Jun 1986

All Science Journal Classification (ASJC) codes

Oncology
Cancer Research

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10.1016/0304-3835(86)90142-4

Cite this

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title = "Partial hepatectomy alters sensitivity of rat hepatocytes to 5-fluorouracil",

abstract = "The sensitivity to 5-fluorouracil (5-FU) and the metabolism of 5-FU in the regenerating rat liver were investigated in vitro. Determination of cell viability using the succinate dehydrogenase inhibition test showed that the hepatocytes of the partially hepatectomized liver were more sensitive to 5-FU, compared to findings in the case of normal liver. The activities of 5-FU phosphorylation of the 3 pathways were higher in the regenerating than in the intact liver and the peak increase was seen 36 h after partial hepatectomy. The activity of 5-FU degradation decreased to about 30% at 36 h and then gradually increased reaching the normal range at 72 h after partial hepatectomy. These results suggest that the metabolic changes of 5-FU may be one of the causes for increased 5-FU susceptibility in the regenerating liver.",

author = "Yoshihiko Maehara and Hideaki Anai and Ryuichiro Tamada and Keizo Sugimachi",

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T1 - Partial hepatectomy alters sensitivity of rat hepatocytes to 5-fluorouracil

AU - Maehara, Yoshihiko

AU - Anai, Hideaki

AU - Tamada, Ryuichiro

AU - Sugimachi, Keizo

PY - 1986/6

Y1 - 1986/6

N2 - The sensitivity to 5-fluorouracil (5-FU) and the metabolism of 5-FU in the regenerating rat liver were investigated in vitro. Determination of cell viability using the succinate dehydrogenase inhibition test showed that the hepatocytes of the partially hepatectomized liver were more sensitive to 5-FU, compared to findings in the case of normal liver. The activities of 5-FU phosphorylation of the 3 pathways were higher in the regenerating than in the intact liver and the peak increase was seen 36 h after partial hepatectomy. The activity of 5-FU degradation decreased to about 30% at 36 h and then gradually increased reaching the normal range at 72 h after partial hepatectomy. These results suggest that the metabolic changes of 5-FU may be one of the causes for increased 5-FU susceptibility in the regenerating liver.

AB - The sensitivity to 5-fluorouracil (5-FU) and the metabolism of 5-FU in the regenerating rat liver were investigated in vitro. Determination of cell viability using the succinate dehydrogenase inhibition test showed that the hepatocytes of the partially hepatectomized liver were more sensitive to 5-FU, compared to findings in the case of normal liver. The activities of 5-FU phosphorylation of the 3 pathways were higher in the regenerating than in the intact liver and the peak increase was seen 36 h after partial hepatectomy. The activity of 5-FU degradation decreased to about 30% at 36 h and then gradually increased reaching the normal range at 72 h after partial hepatectomy. These results suggest that the metabolic changes of 5-FU may be one of the causes for increased 5-FU susceptibility in the regenerating liver.

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Partial hepatectomy alters sensitivity of rat hepatocytes to 5-fluorouracil

Abstract

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