Partial splenic embolization for the treatment of liver cirrhosis with hypersplenism: Assessment of clinical response and liver function

Satoshi Numata, Kimihiro Akagi, Ikuo Sakino, Hisanobu Ogata, Toshiharu Kawadoko, Norihisa Suzuki, Kensuke Nomiyama, Hiroshi Tsuji, Masatoshi Fujishima

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

We have evaluated the efficasy of partial splenic embolization (SE) in the treatment in 10 cirrhotic patients with marked hypersplenism. The mean infarction rate of the spleen was 84%- The change of spleen size, peripheral blood cell counts and liver function tests after SE were investigated during 3 years, and also 10 cirrhotic patients without SE were followed as control. The residual spleens after SE did not enlarged except 1 case with 65% infarction rate of the spleen. In these cases, the SE led not only to a sustained increase in both platelet and white blood cell counts but also to a significant improvement of hepatic function tests (hepaplastin test, total cholesterol and albumin) during observation period. On the other hand, these parameters tended to decrease in control patients without SE. This study suggests that SE performed with a high infarction rate of spleen is an useful therapy for hypersplenism in cirrhosis.

Original languageEnglish
Pages (from-to)526-531
Number of pages6
JournalJapanese Journal of Gastroenterology
Volume94
Issue number8
Publication statusPublished - Dec 1 1997

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Hypersplenism
Liver Cirrhosis
Spleen
Liver
Infarction
Therapeutics
Blood Cell Count
Liver Function Tests
Leukocyte Count
Albumins
Fibrosis
Blood Platelets
Cholesterol
Observation

All Science Journal Classification (ASJC) codes

  • Gastroenterology

Cite this

Partial splenic embolization for the treatment of liver cirrhosis with hypersplenism : Assessment of clinical response and liver function. / Numata, Satoshi; Akagi, Kimihiro; Sakino, Ikuo; Ogata, Hisanobu; Kawadoko, Toshiharu; Suzuki, Norihisa; Nomiyama, Kensuke; Tsuji, Hiroshi; Fujishima, Masatoshi.

In: Japanese Journal of Gastroenterology, Vol. 94, No. 8, 01.12.1997, p. 526-531.

Research output: Contribution to journalArticle

Numata, S, Akagi, K, Sakino, I, Ogata, H, Kawadoko, T, Suzuki, N, Nomiyama, K, Tsuji, H & Fujishima, M 1997, 'Partial splenic embolization for the treatment of liver cirrhosis with hypersplenism: Assessment of clinical response and liver function', Japanese Journal of Gastroenterology, vol. 94, no. 8, pp. 526-531.
Numata, Satoshi ; Akagi, Kimihiro ; Sakino, Ikuo ; Ogata, Hisanobu ; Kawadoko, Toshiharu ; Suzuki, Norihisa ; Nomiyama, Kensuke ; Tsuji, Hiroshi ; Fujishima, Masatoshi. / Partial splenic embolization for the treatment of liver cirrhosis with hypersplenism : Assessment of clinical response and liver function. In: Japanese Journal of Gastroenterology. 1997 ; Vol. 94, No. 8. pp. 526-531.
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AU - Ogata, Hisanobu

AU - Kawadoko, Toshiharu

AU - Suzuki, Norihisa

AU - Nomiyama, Kensuke

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AU - Fujishima, Masatoshi

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