Particle and inhalation exposure in human and monkey computational airway models

Nguyen Lu Phuong, Nguyen Dang Khoa, Kiao Inthavong, Kazuhide Ito

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Regional deposition of inhaled aerosols is essential for assessing health risks from toxic exposure. Upper airway physiology plays a significant role in respiratory defense by filtering micrometer particles, whose deposition mechanism is predominantly inertial impaction and is mainly controlled by airflow characteristics. The monkey is commonly used in tests that study inhalation toxicity as well as in preclinical tests as human surrogates due to their anatomical similarities to humans. Therefore, accurate predictions and an understanding of the inhaled particles and their distribution in monkeys are essential for extrapolating laboratory animal data to humans. The study goals were as follows: (1) to predict the particle deposition based on aerodynamic diameters (1–10 µm) and various steady inspiratory flow rates in computational models of monkey and human upper airways; and (2) to investigate potential differences in inhalation flow and particle deposition between humans and monkeys by comparing numerical simulation results with similar in-vitro and in-vivo measurements from recent literature. The deposition fractions of the monkey’s numerical airway model agreed well with in-vitro and human model data when equivalent Stokes numbers were compared, based on the minimum cross-sectional area as representative of length scale. Vestibule removal efficiencies were predicted to be higher in the monkey model compared with the human model. Our results revealed that the particle transportations were sensitive to the anatomical structure, airway geometry, airflow rates, inflow boundary conditions and particle size.

Original languageEnglish
Pages (from-to)416-428
Number of pages13
JournalInhalation Toxicology
Volume30
Issue number11-12
DOIs
Publication statusPublished - Oct 15 2018

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Inhalation Exposure
Haplorhini
Inhalation
Poisons
Health risks
Physiology
Steady flow
Aerosols
Toxicity
Aerodynamics
Animals
Laboratory Animals
Particle size
Flow rate
Boundary conditions
Particle Size
Geometry
Computer simulation
Health

All Science Journal Classification (ASJC) codes

  • Toxicology
  • Health, Toxicology and Mutagenesis

Cite this

Particle and inhalation exposure in human and monkey computational airway models. / Lu Phuong, Nguyen; Dang Khoa, Nguyen; Inthavong, Kiao; Ito, Kazuhide.

In: Inhalation Toxicology, Vol. 30, No. 11-12, 15.10.2018, p. 416-428.

Research output: Contribution to journalArticle

Lu Phuong, Nguyen ; Dang Khoa, Nguyen ; Inthavong, Kiao ; Ito, Kazuhide. / Particle and inhalation exposure in human and monkey computational airway models. In: Inhalation Toxicology. 2018 ; Vol. 30, No. 11-12. pp. 416-428.
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