Parvocellular and magnocellular visual processing in spinocerebellar degeneration and Parkinson's disease: An event-related potential study

Kenji Arakawa, Shozo Tobimatsu, Motohiro Kato, Jun-Ichi Kira

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Objective: We recorded event-related potentials (ERPs) using appropriate visual stimuli to establish a non-invasive method that separately investigates the parvocellular (P) and magnocellular (M) visual functions, and to evaluate the visual function in spinocerebellar degeneration (SCD) and Parkinson's disease (PD). Methods: Eight SCD and 10 PD patients were compared with 11 age-matched control subjects. In the P-task, subjects were required to discriminate equiluminant red (frequent) and green (rare) random dots. In the M-task, moving random dots on a rotating cylinder (frequent) and those moving irregularly (rare) were discriminated. Results: Control subjects showed an endogenous positive component at 400 ms (P400(p)) with an early exogenous negative potential (N160(p)) in the P-task. In the M-task, N160(m) and P400(m) were recorded. A deuteranope lacked P400(p) with normal P400(m). In SCD, P400(p) latency and N160(p)-P400(p) interval were increased with normal N160(p) latency. N160(m) latency was also increased while N160(m)- P400(m) interval was normal. In PD, there were no significant changes in the P-task but P400(m) latency was increased with normal N160(m) latency. Conclusions: SCD patients may have not only abnormal higher processing in the P-pathway but abnormal fundamental processing in the M-pathway. PD may have impaired higher processing of the M-pathway with the preserved P-function.

Original languageEnglish
Pages (from-to)1048-1057
Number of pages10
JournalClinical Neurophysiology
Volume110
Issue number6
DOIs
Publication statusPublished - Jun 1 1999

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Spinocerebellar Degenerations
Evoked Potentials
Parkinson Disease

All Science Journal Classification (ASJC) codes

  • Sensory Systems
  • Neurology
  • Clinical Neurology
  • Physiology (medical)

Cite this

Parvocellular and magnocellular visual processing in spinocerebellar degeneration and Parkinson's disease : An event-related potential study. / Arakawa, Kenji; Tobimatsu, Shozo; Kato, Motohiro; Kira, Jun-Ichi.

In: Clinical Neurophysiology, Vol. 110, No. 6, 01.06.1999, p. 1048-1057.

Research output: Contribution to journalArticle

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