Passive immunization with bovine milk containing antibodies to a cell surface protein antigen-glucosyltransferase fusion protein protects rats against dental caries

Morihide Mitoma, Takahiko Oho, Naoko Michibata, Kaoru Okano, Yutaka Nakano, Masataka Fukuyama, Toshihiko Koga

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19 Citations (Scopus)

Abstract

Cell surface protein antigen (PAc) and glucosyltransferases (GTF) of Streptococcus mutans are major colonization factors of the organism. We prepared bovine milk containing antibodies against a fusion of the saliva-binding alanine-rich region of PAc with the glucan-binding domain of GTF-I. This study examined the effect of the immune milk on the cariogenicity of S. mutans in a rat model. Concentrated immune milk was fed to rats once a day for 55 days. The group that received immune milk had significantly less caries development than controls.

Original languageEnglish
Pages (from-to)2721-2724
Number of pages4
JournalInfection and Immunity
Volume70
Issue number5
DOIs
Publication statusPublished - Apr 29 2002

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All Science Journal Classification (ASJC) codes

  • Immunology

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