Passive immunization with bovine milk containing antibodies to a cell surface protein antigen-glucosyltransferase fusion protein protects rats against dental caries

Morihide Mitoma, Takahiko Oho, Naoko Michibata, Kaoru Okano, Yutaka Nakano, Masataka Fukuyama, Toshihiko Koga

Research output: Contribution to journalArticle

19 Citations (Scopus)


Cell surface protein antigen (PAc) and glucosyltransferases (GTF) of Streptococcus mutans are major colonization factors of the organism. We prepared bovine milk containing antibodies against a fusion of the saliva-binding alanine-rich region of PAc with the glucan-binding domain of GTF-I. This study examined the effect of the immune milk on the cariogenicity of S. mutans in a rat model. Concentrated immune milk was fed to rats once a day for 55 days. The group that received immune milk had significantly less caries development than controls.

Original languageEnglish
Pages (from-to)2721-2724
Number of pages4
JournalInfection and Immunity
Issue number5
Publication statusPublished - Apr 29 2002


All Science Journal Classification (ASJC) codes

  • Immunology

Cite this