Pathogen-sensing by mincle: Function and molecular aspects

Masahiro Nagata, Zakaria Omahdi, Shou Yamasaki

    Research output: Chapter in Book/Report/Conference proceedingChapter

    6 Citations (Scopus)

    Abstract

    The C-type lectin receptor called Mincle (macrophage-inducible C-type lectin) is a pattern recognition receptor (PRR) mainly expressed by myeloid cells. Over the years, Mincle has been reported to recognize pathogen-associated molecular patterns (PAMPs) from several microorganisms. Among these PAMPs, the most studied is trehalose-6,6-dimycolate (TDM), which is also the most abundant glycolipid present in the cell wall of Mycobacterium tuberculosis. Moreover, it has also been demonstrated that Mincle is involved in fungi recognition, and a growing number of reports show that this PRR may recognize other pathogens. However, in some cases the ligands are still unknown, or the exact role of Mincle in the immune response against these pathogens is unclear. In this chapter, we will begin by presenting the pathogens recognized by Mincle. Then, the Mincle-glycolipid interaction will be described at the molecular level. And last but not least, we will discuss the immune response triggered through Mincle.

    Original languageEnglish
    Title of host publicationC-Type Lectin Receptors in Immunity
    PublisherSpringer Japan
    Pages15-34
    Number of pages20
    ISBN (Electronic)9784431560159
    ISBN (Print)9784431560135
    DOIs
    Publication statusPublished - Jan 1 2016

    All Science Journal Classification (ASJC) codes

    • Medicine(all)
    • Immunology and Microbiology(all)
    • Biochemistry, Genetics and Molecular Biology(all)

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  • Cite this

    Nagata, M., Omahdi, Z., & Yamasaki, S. (2016). Pathogen-sensing by mincle: Function and molecular aspects. In C-Type Lectin Receptors in Immunity (pp. 15-34). Springer Japan. https://doi.org/10.1007/978-4-431-56015-9_2