TY - JOUR
T1 - Pathogenesis of IgG4-related disease
T2 - a critical review
AU - Maehara, Takashi
AU - Moriyama, Masafumi
AU - Nakamura, Seiji
N1 - Publisher Copyright:
© 2018, The Society of The Nippon Dental University.
Copyright:
Copyright 2019 Elsevier B.V., All rights reserved.
PY - 2019/4/15
Y1 - 2019/4/15
N2 - Immunoglobulin G4 (IgG4)-related disease (IgG4-RD) is a chronic, systemic, inflammatory condition of unknown etiology. Histopathologic examination is the key to diagnosis of IgG4-RD. The histopathologic features of IgG4-RD are lymphoplasmacytic infiltration, storiform fibrosis, and obliterative phlebitis. As for fewer than 15 years, IgG4-RD has been recognized as a unified diagnostic entity. CD4 + T and B cells, which likely cause organ damage and disabling tissue fibrosis, constitute the major inflammatory cell population in patients with IgG4-RD. Affected patients with active, untreated disease have a marked expansion of IgG4-secreting plasmablasts in the blood. Important mechanistic insights regarding the pathogenesis of IgG4-RD have been gradually disclosed in recent years. Exploring the role of interactions between these CD4 + T and B cells in patients with IgG4-RD is a highly promising field of investigation. In this review, we focus on CD4 + T cell subsets and the T-cell clones that are involved in the pathogenesis of IgG4-RD.
AB - Immunoglobulin G4 (IgG4)-related disease (IgG4-RD) is a chronic, systemic, inflammatory condition of unknown etiology. Histopathologic examination is the key to diagnosis of IgG4-RD. The histopathologic features of IgG4-RD are lymphoplasmacytic infiltration, storiform fibrosis, and obliterative phlebitis. As for fewer than 15 years, IgG4-RD has been recognized as a unified diagnostic entity. CD4 + T and B cells, which likely cause organ damage and disabling tissue fibrosis, constitute the major inflammatory cell population in patients with IgG4-RD. Affected patients with active, untreated disease have a marked expansion of IgG4-secreting plasmablasts in the blood. Important mechanistic insights regarding the pathogenesis of IgG4-RD have been gradually disclosed in recent years. Exploring the role of interactions between these CD4 + T and B cells in patients with IgG4-RD is a highly promising field of investigation. In this review, we focus on CD4 + T cell subsets and the T-cell clones that are involved in the pathogenesis of IgG4-RD.
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U2 - 10.1007/s10266-018-0377-y
DO - 10.1007/s10266-018-0377-y
M3 - Review article
C2 - 30019169
AN - SCOPUS:85049995201
SN - 1618-1247
VL - 107
SP - 127
EP - 132
JO - Odontology / the Society of the Nippon Dental University
JF - Odontology / the Society of the Nippon Dental University
IS - 2
ER -