Abstract
c-Fos/AP-1 controls the expression of inflammatory cytokines and matrix-degrading matrix metalloproteinases (MMPs) important in arthritis via promoter AP-1 binding motif. Among inflammatory cytokines, IL-1β is the most important inducer of a variety of MMPs, and mainly responsible for cartilage breakdown and osteoclastogenesis. IL-1β and c-Fos/AP-1 influence each other's gene expression and activity, resulting in an orchestrated cross-talk that is crucial to arthritic joint destruction, where TNFα can act synergistically with them. While how to stop the degradation of bone and cartilage, i.e., to control MMP, has long been the central issue in the research of rheumatoid arthritis (RA), selective inhibition of c-Fos/AP-1 does resolve arthritic joint destruction. Thus, the blockade of IL-1β and/or c-Fos/AP-1 can be promising as an effective therapy for rheumatoid joint destruction in addition to the currently available TNFα blocking agents that act mainly on arthritis.
| Original language | English |
|---|---|
| Pages (from-to) | 1539-1543 |
| Number of pages | 5 |
| Journal | Cell Cycle |
| Volume | 8 |
| Issue number | 10 |
| DOIs | |
| Publication status | Published - May 15 2009 |
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All Science Journal Classification (ASJC) codes
- Molecular Biology
- Developmental Biology
- Cell Biology
Cite this
Pathogenesis of rheumatoid arthritis and c-Fos/AP-1. / Shiozawa, Shunichi; Tsumiyama, Ken.
In: Cell Cycle, Vol. 8, No. 10, 15.05.2009, p. 1539-1543.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Pathogenesis of rheumatoid arthritis and c-Fos/AP-1
AU - Shiozawa, Shunichi
AU - Tsumiyama, Ken
PY - 2009/5/15
Y1 - 2009/5/15
N2 - c-Fos/AP-1 controls the expression of inflammatory cytokines and matrix-degrading matrix metalloproteinases (MMPs) important in arthritis via promoter AP-1 binding motif. Among inflammatory cytokines, IL-1β is the most important inducer of a variety of MMPs, and mainly responsible for cartilage breakdown and osteoclastogenesis. IL-1β and c-Fos/AP-1 influence each other's gene expression and activity, resulting in an orchestrated cross-talk that is crucial to arthritic joint destruction, where TNFα can act synergistically with them. While how to stop the degradation of bone and cartilage, i.e., to control MMP, has long been the central issue in the research of rheumatoid arthritis (RA), selective inhibition of c-Fos/AP-1 does resolve arthritic joint destruction. Thus, the blockade of IL-1β and/or c-Fos/AP-1 can be promising as an effective therapy for rheumatoid joint destruction in addition to the currently available TNFα blocking agents that act mainly on arthritis.
AB - c-Fos/AP-1 controls the expression of inflammatory cytokines and matrix-degrading matrix metalloproteinases (MMPs) important in arthritis via promoter AP-1 binding motif. Among inflammatory cytokines, IL-1β is the most important inducer of a variety of MMPs, and mainly responsible for cartilage breakdown and osteoclastogenesis. IL-1β and c-Fos/AP-1 influence each other's gene expression and activity, resulting in an orchestrated cross-talk that is crucial to arthritic joint destruction, where TNFα can act synergistically with them. While how to stop the degradation of bone and cartilage, i.e., to control MMP, has long been the central issue in the research of rheumatoid arthritis (RA), selective inhibition of c-Fos/AP-1 does resolve arthritic joint destruction. Thus, the blockade of IL-1β and/or c-Fos/AP-1 can be promising as an effective therapy for rheumatoid joint destruction in addition to the currently available TNFα blocking agents that act mainly on arthritis.
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UR - http://www.scopus.com/inward/citedby.url?scp=66849143692&partnerID=8YFLogxK
U2 - 10.4161/cc.8.10.8411
DO - 10.4161/cc.8.10.8411
M3 - Review article
C2 - 19395871
AN - SCOPUS:66849143692
VL - 8
SP - 1539
EP - 1543
JO - Cell Cycle
JF - Cell Cycle
SN - 1538-4101
IS - 10
ER -