Pathologic features of superficial esophageal squamous cell carcinoma with lymph node and distal metastasis

Koshi Araki, Shinji Ohno, Akinori Egashira, Hiroshi Saeki, Hidetoshi Kawaguchi, Keizo Sugimachi

Research output: Contribution to journalArticle

120 Citations (Scopus)

Abstract

BACKGROUND. Endoscopic mucosal resection (EMR) is a less invasive localized treatment for patients with esophageal carcinoma. However, indications for EMR use in cases of superficial esophageal carcinoma are controversial. The authors evaluated histopathologic risk factors for lymph node metastasis and recurrence. METHODS. In the specimens resected, the authors examined depth, the superficial area and the area attached to or infiltrating the lamina muscularis mucosa. RESULTS. The authors found that the superficial area and the attached or infiltrated area reflected the depth of the tumor. However, there was a recurrence of esophageal carcinoma even in m3 cases attached only to the lamina muscularis mucosa. CONCLUSIONS. The authors concluded that m1 and m2 esophageal carcinoma had almost no risk of lymph node metastasis and recurrence no matter how extensive the superficial area. In addition, sm2 and sm3 carcinoma have a high frequency of lymph node metastasis and recurrence. M3 and sm1 carcinoma run the risk of lymph node metastasis and recurrence however small the superficial area and the area attached to or infiltrating the lamina muscularis mucosa. Treatment strategies for patients with superficial esophageal carcinoma, including EMR, should take the above findings into account.

Original languageEnglish
Pages (from-to)570-575
Number of pages6
JournalCancer
Volume94
Issue number2
DOIs
Publication statusPublished - Jan 15 2002

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Lymph Nodes
Neoplasm Metastasis
Carcinoma
Recurrence
Mucous Membrane
Esophageal Squamous Cell Carcinoma
Therapeutics
Endoscopic Mucosal Resection
Neoplasms

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Araki, K., Ohno, S., Egashira, A., Saeki, H., Kawaguchi, H., & Sugimachi, K. (2002). Pathologic features of superficial esophageal squamous cell carcinoma with lymph node and distal metastasis. Cancer, 94(2), 570-575. https://doi.org/10.1002/cncr.10190

Pathologic features of superficial esophageal squamous cell carcinoma with lymph node and distal metastasis. / Araki, Koshi; Ohno, Shinji; Egashira, Akinori; Saeki, Hiroshi; Kawaguchi, Hidetoshi; Sugimachi, Keizo.

In: Cancer, Vol. 94, No. 2, 15.01.2002, p. 570-575.

Research output: Contribution to journalArticle

Araki, K, Ohno, S, Egashira, A, Saeki, H, Kawaguchi, H & Sugimachi, K 2002, 'Pathologic features of superficial esophageal squamous cell carcinoma with lymph node and distal metastasis', Cancer, vol. 94, no. 2, pp. 570-575. https://doi.org/10.1002/cncr.10190
Araki, Koshi ; Ohno, Shinji ; Egashira, Akinori ; Saeki, Hiroshi ; Kawaguchi, Hidetoshi ; Sugimachi, Keizo. / Pathologic features of superficial esophageal squamous cell carcinoma with lymph node and distal metastasis. In: Cancer. 2002 ; Vol. 94, No. 2. pp. 570-575.
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AU - Sugimachi, Keizo

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AB - BACKGROUND. Endoscopic mucosal resection (EMR) is a less invasive localized treatment for patients with esophageal carcinoma. However, indications for EMR use in cases of superficial esophageal carcinoma are controversial. The authors evaluated histopathologic risk factors for lymph node metastasis and recurrence. METHODS. In the specimens resected, the authors examined depth, the superficial area and the area attached to or infiltrating the lamina muscularis mucosa. RESULTS. The authors found that the superficial area and the attached or infiltrated area reflected the depth of the tumor. However, there was a recurrence of esophageal carcinoma even in m3 cases attached only to the lamina muscularis mucosa. CONCLUSIONS. The authors concluded that m1 and m2 esophageal carcinoma had almost no risk of lymph node metastasis and recurrence no matter how extensive the superficial area. In addition, sm2 and sm3 carcinoma have a high frequency of lymph node metastasis and recurrence. M3 and sm1 carcinoma run the risk of lymph node metastasis and recurrence however small the superficial area and the area attached to or infiltrating the lamina muscularis mucosa. Treatment strategies for patients with superficial esophageal carcinoma, including EMR, should take the above findings into account.

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