Pathological differences in radical prostatectomy specimens between low- and intermediate-risk prostate cancer patients: Indications for permanent seed implantation monotherapy

Naotaka Sakamoto, Keisuke Monji, Kohei Yuuki, Masahiro Yoshikawa, Atsushi Iguchi

Research output: Contribution to journalArticlepeer-review

Abstract

To clarify the indications for permanent seed implantation monotherapy in patients with intermediaterisk prostate cancer, pathological differences in radical prostatectomy specimens between low- and intermediate-risk prostate cancer were assessed. Fifty-three cases in the low-risk group and 96 cases in the intermediate-risk group had their radical prostatectomy specimens pathologically evaluated between April 2000 and January 2009. Patients with radical prostatectomy specimens of pT2 and Gleason score á 3 + 4 were defined as the favorable group, while those with ≥ pT3a and/or Gleason ≥ score 4 + 3 were defined as the unfavorable group. The favorable group was made up of 67.9%, 81.2%, 73.9%, 73.3%, 23.5% and 24.0% low-risk group cases, ≥ T2a, GS 3 + 3 and 10 ≤ PSA ≤ 20 ng/ml cases, =S T2a, GS 3 + 4 and PSA ≤ 10 ng/ml cases, ≤ T2a, GS 3 + 4 and 10 ≤ PSA 3Š 20 ng/ml cases, < T2a, GS 4 + 3 and PSA ≤ 20 ng/ml cases and T2b, GS ≤ 4 + 3 and PSA ≤ 20 ng/ml cases, respectively. The rate of unfavorable group in cases with ≤ T2a, GS 4 + 3 and PSA ≤ 20 ng/ml, and cases with T2b, GS ≤ 4 + 3 and PSA ≤ 20 ng/ml was statistically higher than that in the low-risk group. Accordingly, cancer volume in cases with T2b, GS ≤ 4 + 3 and PSA ≤ 20 ng/ml was statistically larger than that in the low-risk group. Cancer volume in intermediate-risk groups other than ≤ T2a, GS 3 + 4 and PSA ≤ 10 ng/ml tended to be larger than that in the low-risk group. As for radical prostatectomy specimens, the pathological findings of cases with ≤ T2a, GS 3 + 4 and PSA ≤ 10 ng/ml were similar to those of cases in the low-risk group. The outcome for permanent seed implantation monotherapy with a conventional dose in cases with ≤ T2a, GS 3 + 4 and PSA ≤ 10 ng/ml may be similar to that of cases in the low-risk group from a pathological aspect.

Original languageEnglish
Pages (from-to)65-70
Number of pages6
JournalNishinihon Journal of Urology
Volume72
Issue number2
Publication statusPublished - Feb 1 2010

All Science Journal Classification (ASJC) codes

  • Urology

Fingerprint Dive into the research topics of 'Pathological differences in radical prostatectomy specimens between low- and intermediate-risk prostate cancer patients: Indications for permanent seed implantation monotherapy'. Together they form a unique fingerprint.

Cite this