Pathological manifestation of difference in washout pattern of adrenal hyperplasia on dynamic CT

Akihiro Nishie, Yoshiki Asayama, Kosei Ishigami, Daisuke Kakihara, Tomohiro Nakayama, yasuhiro ushijima, Yukihisa Takayama, Akira Yokomizo, Katsunori Tatsugami, Junichi Inokuchi, nobuhiro fujita, yuichiro kubo, Shinichi Aishima, Masakazu Hirakawa, Hiroshi Honda

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Introduction: The relationship between the washout pattern and constituent cell in adrenal hyperplasia (AH) has not been fully investigated. The purpose of this study was to elucidate the radiological or pathological factors determining the washout pattern of AH on dynamic CT. Methods: Ten patients with 14 surgically proven AHs were enrolled. Dynamic CT was scanned before (pre-contrast image) and 60 seconds (early phase) and 240 seconds (delayed phase) after administration of iodine contrast. The absolute percentage washout (APW) of each nodular lesion was calculated using the following formula: APW(%) = (TAearly-TAdelay)/(TAearly- TApre) x 100, when TApre, TAearly and TAdelay were defined as tumour attenuation values of pre-contrast, early and delayed phases, respectively. Pathologically, the clear cell ratio (CCR) constituting each nodular lesion was qualitatively assessed. Regression analysis was performed to evaluate a correlation between each pair of CCR, TApre, (TAearly-TAdelay) and APW. Results: There was a significant correlation between each pair of CCR, TApre and APW. CCR decreased as TApre increased (r = 0.81, P < 0.001). APW increased as CCR decreased (r = 0.80, P < 0.001) or as TApre increased (r = 0.74, P < 0.01). Conclusions: The key factors of washout pattern of AH on dynamic CT were CCR and TApre. The difference in constituent cell was associated with variability in APW of AH.

Original languageEnglish
Pages (from-to)559-564
Number of pages6
JournalJournal of Medical Imaging and Radiation Oncology
Volume58
Issue number5
DOIs
Publication statusPublished - Oct 1 2014

Fingerprint

Hyperplasia
Iodine
Regression Analysis
Neoplasms

All Science Journal Classification (ASJC) codes

  • Oncology
  • Radiology Nuclear Medicine and imaging

Cite this

@article{e0712e4ba03f475093b42d1b73e02e80,
title = "Pathological manifestation of difference in washout pattern of adrenal hyperplasia on dynamic CT",
abstract = "Introduction: The relationship between the washout pattern and constituent cell in adrenal hyperplasia (AH) has not been fully investigated. The purpose of this study was to elucidate the radiological or pathological factors determining the washout pattern of AH on dynamic CT. Methods: Ten patients with 14 surgically proven AHs were enrolled. Dynamic CT was scanned before (pre-contrast image) and 60 seconds (early phase) and 240 seconds (delayed phase) after administration of iodine contrast. The absolute percentage washout (APW) of each nodular lesion was calculated using the following formula: APW({\%}) = (TAearly-TAdelay)/(TAearly- TApre) x 100, when TApre, TAearly and TAdelay were defined as tumour attenuation values of pre-contrast, early and delayed phases, respectively. Pathologically, the clear cell ratio (CCR) constituting each nodular lesion was qualitatively assessed. Regression analysis was performed to evaluate a correlation between each pair of CCR, TApre, (TAearly-TAdelay) and APW. Results: There was a significant correlation between each pair of CCR, TApre and APW. CCR decreased as TApre increased (r = 0.81, P < 0.001). APW increased as CCR decreased (r = 0.80, P < 0.001) or as TApre increased (r = 0.74, P < 0.01). Conclusions: The key factors of washout pattern of AH on dynamic CT were CCR and TApre. The difference in constituent cell was associated with variability in APW of AH.",
author = "Akihiro Nishie and Yoshiki Asayama and Kosei Ishigami and Daisuke Kakihara and Tomohiro Nakayama and yasuhiro ushijima and Yukihisa Takayama and Akira Yokomizo and Katsunori Tatsugami and Junichi Inokuchi and nobuhiro fujita and yuichiro kubo and Shinichi Aishima and Masakazu Hirakawa and Hiroshi Honda",
year = "2014",
month = "10",
day = "1",
doi = "10.1111/1754-9485.12211",
language = "English",
volume = "58",
pages = "559--564",
journal = "Journal of Medical Imaging and Radiation Oncology",
issn = "1754-9477",
publisher = "Wiley-Blackwell",
number = "5",

}

TY - JOUR

T1 - Pathological manifestation of difference in washout pattern of adrenal hyperplasia on dynamic CT

AU - Nishie, Akihiro

AU - Asayama, Yoshiki

AU - Ishigami, Kosei

AU - Kakihara, Daisuke

AU - Nakayama, Tomohiro

AU - ushijima, yasuhiro

AU - Takayama, Yukihisa

AU - Yokomizo, Akira

AU - Tatsugami, Katsunori

AU - Inokuchi, Junichi

AU - fujita, nobuhiro

AU - kubo, yuichiro

AU - Aishima, Shinichi

AU - Hirakawa, Masakazu

AU - Honda, Hiroshi

PY - 2014/10/1

Y1 - 2014/10/1

N2 - Introduction: The relationship between the washout pattern and constituent cell in adrenal hyperplasia (AH) has not been fully investigated. The purpose of this study was to elucidate the radiological or pathological factors determining the washout pattern of AH on dynamic CT. Methods: Ten patients with 14 surgically proven AHs were enrolled. Dynamic CT was scanned before (pre-contrast image) and 60 seconds (early phase) and 240 seconds (delayed phase) after administration of iodine contrast. The absolute percentage washout (APW) of each nodular lesion was calculated using the following formula: APW(%) = (TAearly-TAdelay)/(TAearly- TApre) x 100, when TApre, TAearly and TAdelay were defined as tumour attenuation values of pre-contrast, early and delayed phases, respectively. Pathologically, the clear cell ratio (CCR) constituting each nodular lesion was qualitatively assessed. Regression analysis was performed to evaluate a correlation between each pair of CCR, TApre, (TAearly-TAdelay) and APW. Results: There was a significant correlation between each pair of CCR, TApre and APW. CCR decreased as TApre increased (r = 0.81, P < 0.001). APW increased as CCR decreased (r = 0.80, P < 0.001) or as TApre increased (r = 0.74, P < 0.01). Conclusions: The key factors of washout pattern of AH on dynamic CT were CCR and TApre. The difference in constituent cell was associated with variability in APW of AH.

AB - Introduction: The relationship between the washout pattern and constituent cell in adrenal hyperplasia (AH) has not been fully investigated. The purpose of this study was to elucidate the radiological or pathological factors determining the washout pattern of AH on dynamic CT. Methods: Ten patients with 14 surgically proven AHs were enrolled. Dynamic CT was scanned before (pre-contrast image) and 60 seconds (early phase) and 240 seconds (delayed phase) after administration of iodine contrast. The absolute percentage washout (APW) of each nodular lesion was calculated using the following formula: APW(%) = (TAearly-TAdelay)/(TAearly- TApre) x 100, when TApre, TAearly and TAdelay were defined as tumour attenuation values of pre-contrast, early and delayed phases, respectively. Pathologically, the clear cell ratio (CCR) constituting each nodular lesion was qualitatively assessed. Regression analysis was performed to evaluate a correlation between each pair of CCR, TApre, (TAearly-TAdelay) and APW. Results: There was a significant correlation between each pair of CCR, TApre and APW. CCR decreased as TApre increased (r = 0.81, P < 0.001). APW increased as CCR decreased (r = 0.80, P < 0.001) or as TApre increased (r = 0.74, P < 0.01). Conclusions: The key factors of washout pattern of AH on dynamic CT were CCR and TApre. The difference in constituent cell was associated with variability in APW of AH.

UR - http://www.scopus.com/inward/record.url?scp=84907904158&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84907904158&partnerID=8YFLogxK

U2 - 10.1111/1754-9485.12211

DO - 10.1111/1754-9485.12211

M3 - Article

C2 - 25043666

AN - SCOPUS:84907904158

VL - 58

SP - 559

EP - 564

JO - Journal of Medical Imaging and Radiation Oncology

JF - Journal of Medical Imaging and Radiation Oncology

SN - 1754-9477

IS - 5

ER -