Pathophysiological roles of NADPH oxidase/Nox family proteins in the vascular system review and perspective

Tetsuro Ago; Junya Kuroda; Masahiro Kamouchi; Junichi Sadoshima; Takanari Kitazono

doi:10.1253/circj.CJ-11-0388

Pathophysiological roles of NADPH oxidase/Nox family proteins in the vascular system review and perspective

Tetsuro Ago, Junya Kuroda, Masahiro Kamouchi, Junichi Sadoshima, Takanari Kitazono

Research output: Contribution to journal › Review article › peer-review

76 Citations (Scopus)

Abstract

It has been established that oxidative stress plays a crucial role in the development and progression of vascular diseases. Besides the mitochondria, the NADPH oxidase/Nox family proteins are now thought to be important origins of the reactive oxygen species that underlie various vascular disease states, such as hypertension, atherosclerosis, angiogenesis, and ischemia/reperfusion injury. This review summarizes the basis of vascular Nox proteins and discusses their pathophysiological roles in the vascular system.

Original language	English
Pages (from-to)	1791-1800
Number of pages	10
Journal	Circulation Journal
Volume	75
Issue number	8
DOIs	https://doi.org/10.1253/circj.CJ-11-0388
Publication status	Published - Aug 2011

All Science Journal Classification (ASJC) codes

Cardiology and Cardiovascular Medicine

Access to Document

10.1253/circj.CJ-11-0388

Cite this

@article{e677f885cef34c8593dcc933098a4d6e,

title = "Pathophysiological roles of NADPH oxidase/Nox family proteins in the vascular system review and perspective",

abstract = "It has been established that oxidative stress plays a crucial role in the development and progression of vascular diseases. Besides the mitochondria, the NADPH oxidase/Nox family proteins are now thought to be important origins of the reactive oxygen species that underlie various vascular disease states, such as hypertension, atherosclerosis, angiogenesis, and ischemia/reperfusion injury. This review summarizes the basis of vascular Nox proteins and discusses their pathophysiological roles in the vascular system.",

author = "Tetsuro Ago and Junya Kuroda and Masahiro Kamouchi and Junichi Sadoshima and Takanari Kitazono",

year = "2011",

month = aug,

doi = "10.1253/circj.CJ-11-0388",

language = "English",

volume = "75",

pages = "1791--1800",

journal = "Circulation Journal",

issn = "1346-9843",

publisher = "Japanese Circulation Society",

number = "8",

}

TY - JOUR

T1 - Pathophysiological roles of NADPH oxidase/Nox family proteins in the vascular system review and perspective

AU - Ago, Tetsuro

AU - Kuroda, Junya

AU - Kamouchi, Masahiro

AU - Sadoshima, Junichi

AU - Kitazono, Takanari

PY - 2011/8

Y1 - 2011/8

N2 - It has been established that oxidative stress plays a crucial role in the development and progression of vascular diseases. Besides the mitochondria, the NADPH oxidase/Nox family proteins are now thought to be important origins of the reactive oxygen species that underlie various vascular disease states, such as hypertension, atherosclerosis, angiogenesis, and ischemia/reperfusion injury. This review summarizes the basis of vascular Nox proteins and discusses their pathophysiological roles in the vascular system.

AB - It has been established that oxidative stress plays a crucial role in the development and progression of vascular diseases. Besides the mitochondria, the NADPH oxidase/Nox family proteins are now thought to be important origins of the reactive oxygen species that underlie various vascular disease states, such as hypertension, atherosclerosis, angiogenesis, and ischemia/reperfusion injury. This review summarizes the basis of vascular Nox proteins and discusses their pathophysiological roles in the vascular system.

UR - http://www.scopus.com/inward/record.url?scp=79960792993&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79960792993&partnerID=8YFLogxK

U2 - 10.1253/circj.CJ-11-0388

DO - 10.1253/circj.CJ-11-0388

M3 - Review article

C2 - 21673456

AN - SCOPUS:79960792993

VL - 75

SP - 1791

EP - 1800

JO - Circulation Journal

JF - Circulation Journal

SN - 1346-9843

IS - 8

ER -

Pathophysiological roles of NADPH oxidase/Nox family proteins in the vascular system review and perspective

Abstract

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this