Pathophysiological roles of NADPH oxidase/Nox family proteins in the vascular system review and perspective

Tetsuro Ago; Junya Kuroda; Masahiro Kamouchi; Junichi Sadoshima; Takanari Kitazono

doi:10.1253/circj.CJ-11-0388

Pathophysiological roles of NADPH oxidase/Nox family proteins in the vascular system review and perspective

Tetsuro Ago, Junya Kuroda, Masahiro Kamouchi, Junichi Sadoshima, Takanari Kitazono

Research output: Contribution to journal › Review article › peer-review

73 Citations (Scopus)

Abstract

It has been established that oxidative stress plays a crucial role in the development and progression of vascular diseases. Besides the mitochondria, the NADPH oxidase/Nox family proteins are now thought to be important origins of the reactive oxygen species that underlie various vascular disease states, such as hypertension, atherosclerosis, angiogenesis, and ischemia/reperfusion injury. This review summarizes the basis of vascular Nox proteins and discusses their pathophysiological roles in the vascular system.

Original language	English
Pages (from-to)	1791-1800
Number of pages	10
Journal	Circulation Journal
Volume	75
Issue number	8
DOIs	https://doi.org/10.1253/circj.CJ-11-0388
Publication status	Published - Aug 2011

All Science Journal Classification (ASJC) codes

Cardiology and Cardiovascular Medicine

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abstract = "It has been established that oxidative stress plays a crucial role in the development and progression of vascular diseases. Besides the mitochondria, the NADPH oxidase/Nox family proteins are now thought to be important origins of the reactive oxygen species that underlie various vascular disease states, such as hypertension, atherosclerosis, angiogenesis, and ischemia/reperfusion injury. This review summarizes the basis of vascular Nox proteins and discusses their pathophysiological roles in the vascular system.",

author = "Tetsuro Ago and Junya Kuroda and Masahiro Kamouchi and Junichi Sadoshima and Takanari Kitazono",

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AU - Sadoshima, Junichi

AU - Kitazono, Takanari

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AB - It has been established that oxidative stress plays a crucial role in the development and progression of vascular diseases. Besides the mitochondria, the NADPH oxidase/Nox family proteins are now thought to be important origins of the reactive oxygen species that underlie various vascular disease states, such as hypertension, atherosclerosis, angiogenesis, and ischemia/reperfusion injury. This review summarizes the basis of vascular Nox proteins and discusses their pathophysiological roles in the vascular system.

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Pathophysiological roles of NADPH oxidase/Nox family proteins in the vascular system review and perspective

Abstract

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