Abstract
It has been established that oxidative stress plays a crucial role in the development and progression of vascular diseases. Besides the mitochondria, the NADPH oxidase/Nox family proteins are now thought to be important origins of the reactive oxygen species that underlie various vascular disease states, such as hypertension, atherosclerosis, angiogenesis, and ischemia/reperfusion injury. This review summarizes the basis of vascular Nox proteins and discusses their pathophysiological roles in the vascular system.
Original language | English |
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Pages (from-to) | 1791-1800 |
Number of pages | 10 |
Journal | Circulation Journal |
Volume | 75 |
Issue number | 8 |
DOIs | |
Publication status | Published - Aug 2011 |
All Science Journal Classification (ASJC) codes
- Cardiology and Cardiovascular Medicine