Patients with multiple sclerosis show increased oxidative stress markers and somatic telomere length shortening

Jing Zhi Guan, Wei Ping Guan, Toyoki Maeda, Xie Guoqing, Wan GuangZhi, Naoki Makino

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Lipid peroxidation due to oxidative stress (OS) may play an important role in the pathogenesis of chronic systemic inflammatory diseases such as multiple sclerosis (MS). Telomeres, repeated sequences that cap chromosome ends, undergo shortening with each cycle of cell division, resulting in cellular senescence. Research regarding telomere shortening has provided novel insight into the pathogenesis of various diseases. We hypothesized that OS damage leads to inflammatory reactions, which subsequently shortens the telomere length in MS. We enrolled 59 patients with MS, and age- and gender-matched 60 healthy controls. We divided MS subjects into three groups matched for age and gender according to the severity of disability: relatively benign course (BMS), secondary progressive MS, and primary progressive MS (PPMS). We analyzed the telomere length in peripheral blood mononuclear cells and the 8-iso-PGF2α concentration in urine, a reliable and stable marker of lipid peroxidation in vivo. The data showed significant higher levels of urinary 8-iso-PGF2α in MS subjects than in the controls. The lag-time, which represents the direct measurement of the resistance of low-density lipoprotein to oxidation, was shorter in the PPMS subjects than in the groups. Compared to that observed in the controls, the mean telomere length was significantly shorter in the PPMS group, whereas no significant telomere shortening was found between the controls and other subjects. Our data suggest that a decreased telomere length and enhanced lipid peroxidation reflects the severest stage of MS.

Original languageEnglish
Pages (from-to)183-187
Number of pages5
JournalMolecular and cellular biochemistry
Volume400
Issue number1-2
DOIs
Publication statusPublished - Jan 1 2014

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Telomere Shortening
Oxidative stress
Multiple Sclerosis
Oxidative Stress
Telomere
Dinoprost
Lipids
Chronic Progressive Multiple Sclerosis
Lipid Peroxidation
Chromosomes
LDL Lipoproteins
Blood
Cell Aging
Cells
Oxidation
Blood Cells
Cell Cycle
Research Design
Age Groups
Urine

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Clinical Biochemistry
  • Cell Biology

Cite this

Patients with multiple sclerosis show increased oxidative stress markers and somatic telomere length shortening. / Guan, Jing Zhi; Guan, Wei Ping; Maeda, Toyoki; Guoqing, Xie; GuangZhi, Wan; Makino, Naoki.

In: Molecular and cellular biochemistry, Vol. 400, No. 1-2, 01.01.2014, p. 183-187.

Research output: Contribution to journalArticle

Guan, Jing Zhi ; Guan, Wei Ping ; Maeda, Toyoki ; Guoqing, Xie ; GuangZhi, Wan ; Makino, Naoki. / Patients with multiple sclerosis show increased oxidative stress markers and somatic telomere length shortening. In: Molecular and cellular biochemistry. 2014 ; Vol. 400, No. 1-2. pp. 183-187.
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