Patterns and time of recurrence after complete resection of esophageal cancer

Masahiko Sugiyama, Masaru Morita, Rintaro Yoshida, Kouji Andou, Akinori Egashira, Ohga Takefumi, Hiroshi Saeki, Eiji Oki, Yoshihiro Kakeji, Yoshihisa Sakaguchi, Yoshihiko Maehara

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Abstract

Purpose The results and outcomes of surgical resection for esophageal carcinoma have improved remarkably in recent years; however, recurrence still frequently develops, even after complete resection. The purpose of this study is to clarify the characteristics of recurrence in this patient population. Methods Among 208 patients, who underwent R0 resection for esophageal carcinoma, recurrence developed in 61. Clinical data were available for 56 of these patients, who were the subjects of this study. We evaluated the time, patterns, and treatment of recurrence in these patients. Results Recurrence developed within 1 and 2 years after esophagectomy in 71 and 84% of the patients, respectively, and was classified as loco-regional (54%), hematogenous (36%), or mixed type (10%). The prognosis of patients with loco-regional recurrence tended to be better than that of those with distant metastasis, although the difference was not significant (P = 0.088). Patients with recurrence treated by chemotherapy alone or multimodal therapy, such as radiation or surgery combined with systemic chemotherapy, survived significantly longer than those with untreatable recurrence (P = 0.016). Conclusion These findings reinforce the importance of careful follow-up for both loco-regional and hematogenous recurrence after esophagectomy, particularly during the first 2 years.

Original languageEnglish
Pages (from-to)752-758
Number of pages7
JournalSurgery today
Volume42
Issue number8
DOIs
Publication statusPublished - Aug 1 2012

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Esophageal Neoplasms
Recurrence
Esophagectomy
Carcinoma
Drug Therapy
Radiation
Neoplasm Metastasis
Therapeutics

All Science Journal Classification (ASJC) codes

  • Surgery

Cite this

Sugiyama, M., Morita, M., Yoshida, R., Andou, K., Egashira, A., Takefumi, O., ... Maehara, Y. (2012). Patterns and time of recurrence after complete resection of esophageal cancer. Surgery today, 42(8), 752-758. https://doi.org/10.1007/s00595-012-0133-9

Patterns and time of recurrence after complete resection of esophageal cancer. / Sugiyama, Masahiko; Morita, Masaru; Yoshida, Rintaro; Andou, Kouji; Egashira, Akinori; Takefumi, Ohga; Saeki, Hiroshi; Oki, Eiji; Kakeji, Yoshihiro; Sakaguchi, Yoshihisa; Maehara, Yoshihiko.

In: Surgery today, Vol. 42, No. 8, 01.08.2012, p. 752-758.

Research output: Contribution to journalArticle

Sugiyama, M, Morita, M, Yoshida, R, Andou, K, Egashira, A, Takefumi, O, Saeki, H, Oki, E, Kakeji, Y, Sakaguchi, Y & Maehara, Y 2012, 'Patterns and time of recurrence after complete resection of esophageal cancer', Surgery today, vol. 42, no. 8, pp. 752-758. https://doi.org/10.1007/s00595-012-0133-9
Sugiyama, Masahiko ; Morita, Masaru ; Yoshida, Rintaro ; Andou, Kouji ; Egashira, Akinori ; Takefumi, Ohga ; Saeki, Hiroshi ; Oki, Eiji ; Kakeji, Yoshihiro ; Sakaguchi, Yoshihisa ; Maehara, Yoshihiko. / Patterns and time of recurrence after complete resection of esophageal cancer. In: Surgery today. 2012 ; Vol. 42, No. 8. pp. 752-758.
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