PBPK-CFD hybrid approach for estimating airway tissue dosimetry: Development of Computer Simulated Person with numerical respiratory tract model-part3

Research output: Contribution to journalArticle

Abstract

The effects of air pollution found in indoors and prevention of exposure to hazardous chemical compounds are an important issue in the interest of public health. In this research, Computer Simulated Person (CSP) that integrated thermo-regulation and numerical respiratory tract model was developed for applying comprehensive assessment of health risk caused by indoor environmental quality problem. This paper (Part 3) treats the development of integrated numerical simulation method of Physiologically Based Pharmaco-Kinetic (PBPK) model and Computational Fluid Dynamics (CFD) for estimating respiratory tract tissue dosimetry. The PBPK-CFD model was incorporated into numerical airway mode that integrated into CSP. Here, inhalation exposure and its health impact were analyzed by using PBPK-CFD-CSP model under the indoor environmental condition of formaldehyde emitted from building materials.

Original languageEnglish
Pages (from-to)971-978
Number of pages8
JournalJournal of Environmental Engineering (Japan)
Volume81
Issue number729
DOIs
Publication statusPublished - Nov 1 2016

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Pharmacokinetics
Dosimetry
Computational fluid dynamics
Tissue
Chemical compounds
Health risks
Public health
Air pollution
Formaldehyde
Dynamic models
Health
Computer simulation

All Science Journal Classification (ASJC) codes

  • Environmental Engineering

Cite this

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abstract = "The effects of air pollution found in indoors and prevention of exposure to hazardous chemical compounds are an important issue in the interest of public health. In this research, Computer Simulated Person (CSP) that integrated thermo-regulation and numerical respiratory tract model was developed for applying comprehensive assessment of health risk caused by indoor environmental quality problem. This paper (Part 3) treats the development of integrated numerical simulation method of Physiologically Based Pharmaco-Kinetic (PBPK) model and Computational Fluid Dynamics (CFD) for estimating respiratory tract tissue dosimetry. The PBPK-CFD model was incorporated into numerical airway mode that integrated into CSP. Here, inhalation exposure and its health impact were analyzed by using PBPK-CFD-CSP model under the indoor environmental condition of formaldehyde emitted from building materials.",
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