PC3 is involved in the shift from proliferation to differentiation and maturation in spiral ganglion neurons

Momoko Hayashida, Ryosei Minoda, Yohei Shinmyo, Kunimasa Ohta, Hideaki Tanaka, Eiji Yumoto

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

PC3 is a member of the BTG/Tob family of antiproliferative genes. Here, we report the results of an analysis of PC3 protein expression in spiral ganglion neurons of the rat cochlea at embryonic days 16 (E16) and 20 (E20), and postnatal days 4 (P4) and 7 (P7). PC3 expression was observed in the cytoplasm of ganglion neurons at E16 and E20, and this protein had translocated to the nucleus by P4. The expression of Ki-67, a nuclear antigen expressed by dividing cells, was detected in ganglion neurons at E16 and E20, but not at P4 or P7. These results suggest that PC3 is involved in the shift from proliferation to differentiation and maturation in the ganglion neurons of the rat cochlea.

Original languageEnglish
Pages (from-to)90-93
Number of pages4
JournalNeuroReport
Volume21
Issue number2
DOIs
Publication statusPublished - Apr 5 2010
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

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