TY - JOUR
T1 - Pediatric follicular lymphoma in Japan
AU - Lymphoma Committee and Japanese Pediatric Leukemia/Lymphoma Study Group
AU - Kobayashi, Ryoji
AU - Tanaka, Fumiko
AU - Nakazawa, Atsuko
AU - Ueyama, Jun ichi
AU - Sunami, Shosuke
AU - Mitsui, Tetsuo
AU - Koga, Yuhki
AU - Mori, Takeshi
AU - Osumi, Tomoo
AU - Fukano, Reiji
AU - Ohki, Kentaro
AU - Sekimizu, Masahiro
AU - Fujita, Naoto
AU - Kamei, Michi
AU - Mori, Tetsuya
N1 - Funding Information:
Acknowledgements This research was supported by Practical Research for Innovative Cancer Control of the Japan Agency for Medical Research and Development (AMED). We also thank the doctors of the JPLSG for their participation this study.
PY - 2017/6/1
Y1 - 2017/6/1
N2 - Follicular lymphoma (FL) is quite rare in children. There have been only two major reports on pediatric FL. The present retrospective study on pediatric FL in Japan, including FL with diffuse large B cell lymphoma (DLBCL), analyzed data from 1991 to 2014. Twenty-two patients with pediatric FL were analyzed. Sixteen patients were boys and six were girls. Median age of onset was 9 years (range 4–17 years). In 11 patients, DLBCL co-existed with FL. The initial lesions involved cervical lesions in 16 patients, and the abdomen in six. With regard to stage of disease at diagnosis, 17 patients were at stage I or II, four were at stage III, and one was at stage IV. Chemotherapy was administered in 18 patients, and only resection was performed in four patients. Mature B lymphoma regimens were selected for 17 patients who received chemotherapy. Although two patients relapsed, all patients are currently alive and disease free. The median follow-up period was 54.5 months (range 6–126 months). Patients having FL with DLBCL were younger compared with those having FL, and this disease was more frequently observed in female patients. Our data revealed that FL in Japanese children is a tumor with good prognosis, as in reports from the United States and Europe.
AB - Follicular lymphoma (FL) is quite rare in children. There have been only two major reports on pediatric FL. The present retrospective study on pediatric FL in Japan, including FL with diffuse large B cell lymphoma (DLBCL), analyzed data from 1991 to 2014. Twenty-two patients with pediatric FL were analyzed. Sixteen patients were boys and six were girls. Median age of onset was 9 years (range 4–17 years). In 11 patients, DLBCL co-existed with FL. The initial lesions involved cervical lesions in 16 patients, and the abdomen in six. With regard to stage of disease at diagnosis, 17 patients were at stage I or II, four were at stage III, and one was at stage IV. Chemotherapy was administered in 18 patients, and only resection was performed in four patients. Mature B lymphoma regimens were selected for 17 patients who received chemotherapy. Although two patients relapsed, all patients are currently alive and disease free. The median follow-up period was 54.5 months (range 6–126 months). Patients having FL with DLBCL were younger compared with those having FL, and this disease was more frequently observed in female patients. Our data revealed that FL in Japanese children is a tumor with good prognosis, as in reports from the United States and Europe.
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U2 - 10.1007/s12185-017-2209-1
DO - 10.1007/s12185-017-2209-1
M3 - Article
C2 - 28271414
AN - SCOPUS:85014559817
SN - 0925-5710
VL - 105
SP - 849
EP - 853
JO - International Journal of Hematology
JF - International Journal of Hematology
IS - 6
ER -