TY - JOUR
T1 - Pediatric glioma
T2 - An update of diagnosis, biology, and treatment
AU - Funakoshi, Yusuke
AU - Hata, Nobuhiro
AU - Kuga, Daisuke
AU - Hatae, Ryusuke
AU - Sangatsuda, Yuhei
AU - Fujioka, Yutaka
AU - Takigawa, Kosuke
AU - Mizoguchi, Masahiro
N1 - Funding Information:
Funding: This work was supported by the Japanese Society for the Promotion of Science Grants‐in‐ Aid for Scientific Research (JSPS KAKENHI) Award (Grant No. JP20K09392, JP18K08970, JP19K17673, and JP20K17972).
Publisher Copyright:
© by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2021/2
Y1 - 2021/2
N2 - Recent research has promoted elucidation of the diverse biological processes that occur in pediatric central nervous system (CNS) tumors. Molecular genetic analysis is essential not only for proper classification, but also for monitoring biological behavior and clinical management of tumors. Ever since the 2016 World Health Organization classification of CNS tumors, molecular profiling has become an indispensable step in the diagnosis, prediction of prognosis, and treatment of pediatric as well as adult CNS tumors. These molecular data are changing diagnosis, leading to new guidelines, and offering novel molecular targeted therapies. The Consortium to Inform Molecular and Practical Approaches to CNS Tumor Taxonomy (cIMPACT‐NOW) makes practical recommendations using recent advances in CNS tumor classification, particularly in molecular discernment of these neoplasms as morphology‐based classification of tumors is being replaced by molecular‐based classification. In this article, we summarize recent knowledge to provide an overview of pediatric gliomas, which are major pediatric CNS tumors, and describe recent developments in strategies employed for their diagnosis and treatment.
AB - Recent research has promoted elucidation of the diverse biological processes that occur in pediatric central nervous system (CNS) tumors. Molecular genetic analysis is essential not only for proper classification, but also for monitoring biological behavior and clinical management of tumors. Ever since the 2016 World Health Organization classification of CNS tumors, molecular profiling has become an indispensable step in the diagnosis, prediction of prognosis, and treatment of pediatric as well as adult CNS tumors. These molecular data are changing diagnosis, leading to new guidelines, and offering novel molecular targeted therapies. The Consortium to Inform Molecular and Practical Approaches to CNS Tumor Taxonomy (cIMPACT‐NOW) makes practical recommendations using recent advances in CNS tumor classification, particularly in molecular discernment of these neoplasms as morphology‐based classification of tumors is being replaced by molecular‐based classification. In this article, we summarize recent knowledge to provide an overview of pediatric gliomas, which are major pediatric CNS tumors, and describe recent developments in strategies employed for their diagnosis and treatment.
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U2 - 10.3390/cancers13040758
DO - 10.3390/cancers13040758
M3 - Review article
AN - SCOPUS:85100649619
SN - 2072-6694
VL - 13
SP - 1
EP - 17
JO - Cancers
JF - Cancers
IS - 4
M1 - 758
ER -
