Pediatric soft tissue tumor of the upper arm with LMNA-NTRK1 fusion

Shinji Kohsaka, Tsuyoshi Saito, Keisuke Akaike, Yoshiyuki Suehara, Takuo Hayashi, Tatsuya Takagi, Kazuo Kaneko, Toshihide Ueno, Shinya Kojima, Kenichi Kouhashi, Hiroyuki Mano, Yoshinao Oda, Takashi Yao

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

A 6-year-old girl was admitted to our hospital because of the presence of a slow-growing tumor in her right elbow. Biopsy specimens showed a round to spindle cell neoplasm with uncertain malignant potential, leading to the decision of surgical resection. Histologically, the resected tumor was encapsulated by fibrous tissue but focally invaded the surrounding skeletal muscles. The tumor was composed of ganglion cell–like short spindle cells with lymphocytic infiltration in the collagenous background. Tumor cells with large bizarre nuclei were occasionally observed, and multinucleated giant cells were scattered at the periphery. Hemangiopericytoma-like patterns and adipose tissue elements were not evident, and mitotic figures were rarely observed (<1 per 10 high-power fields). Immunohistochemically, the tumor cells were positive for S-100 and CD34 and focally positive for epithelial membrane antigen and AE1/AE3. RNA sequencing and subsequent reverse-transcription polymerase chain reaction revealed alternative splicing forms of LMNA-NTRK1 fusion (Ex2-Ex10 and Ex2-Ex15).

Original languageEnglish
Pages (from-to)167-173
Number of pages7
JournalHuman Pathology
Volume72
DOIs
Publication statusPublished - Feb 1 2018

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Arm
Pediatrics
Neoplasms
RNA Sequence Analysis
Hemangiopericytoma
Mucin-1
Alternative Splicing
Giant Cells
Elbow
Ganglia
Reverse Transcription
Adipose Tissue
Skeletal Muscle
Biopsy
Polymerase Chain Reaction

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine

Cite this

Kohsaka, S., Saito, T., Akaike, K., Suehara, Y., Hayashi, T., Takagi, T., ... Yao, T. (2018). Pediatric soft tissue tumor of the upper arm with LMNA-NTRK1 fusion. Human Pathology, 72, 167-173. https://doi.org/10.1016/j.humpath.2017.08.017

Pediatric soft tissue tumor of the upper arm with LMNA-NTRK1 fusion. / Kohsaka, Shinji; Saito, Tsuyoshi; Akaike, Keisuke; Suehara, Yoshiyuki; Hayashi, Takuo; Takagi, Tatsuya; Kaneko, Kazuo; Ueno, Toshihide; Kojima, Shinya; Kouhashi, Kenichi; Mano, Hiroyuki; Oda, Yoshinao; Yao, Takashi.

In: Human Pathology, Vol. 72, 01.02.2018, p. 167-173.

Research output: Contribution to journalArticle

Kohsaka, S, Saito, T, Akaike, K, Suehara, Y, Hayashi, T, Takagi, T, Kaneko, K, Ueno, T, Kojima, S, Kouhashi, K, Mano, H, Oda, Y & Yao, T 2018, 'Pediatric soft tissue tumor of the upper arm with LMNA-NTRK1 fusion', Human Pathology, vol. 72, pp. 167-173. https://doi.org/10.1016/j.humpath.2017.08.017
Kohsaka S, Saito T, Akaike K, Suehara Y, Hayashi T, Takagi T et al. Pediatric soft tissue tumor of the upper arm with LMNA-NTRK1 fusion. Human Pathology. 2018 Feb 1;72:167-173. https://doi.org/10.1016/j.humpath.2017.08.017
Kohsaka, Shinji ; Saito, Tsuyoshi ; Akaike, Keisuke ; Suehara, Yoshiyuki ; Hayashi, Takuo ; Takagi, Tatsuya ; Kaneko, Kazuo ; Ueno, Toshihide ; Kojima, Shinya ; Kouhashi, Kenichi ; Mano, Hiroyuki ; Oda, Yoshinao ; Yao, Takashi. / Pediatric soft tissue tumor of the upper arm with LMNA-NTRK1 fusion. In: Human Pathology. 2018 ; Vol. 72. pp. 167-173.
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