PEG-modified gold nanorods with a stealth character for in vivo applications

Takuro Niidome, Masato Yamagata, Yuri Okamoto, Yasuyuki Akiyama, Hironobu Takahashi, Takahito Kawano, Yoshiki Katayama, Yasuro Niidome

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915 Citations (Scopus)

Abstract

Gold nanorods prepared in hexadecyltrimethylammonium bromide (CTAB) solution are expected to provide novel materials for photothermal therapy and photo-controlled drug delivery systems. Since gold nanorods stabilized with CTAB show strong cytotoxicity, we developed a technique to modify these with polyethyleneglycol (PEG) for medical applications. PEG-modification was achieved by adding mPEG-SH in the CTAB solution, then, excess CTAB was removed by dialysis. PEG-modified gold nanoparticles showed a nearly neutral surface, and had little cytotoxicity in vitro. Following intravenous injection into mice, 54% of injected PEG-modified gold nanoparticles were found in blood at 0.5 h after intravenous injection, whereas most of gold was detected in the liver in the case of original gold nanorods stabilized with CTAB.

Original languageEnglish
Pages (from-to)343-347
Number of pages5
JournalJournal of Controlled Release
Volume114
Issue number3
DOIs
Publication statusPublished - Sep 12 2006

All Science Journal Classification (ASJC) codes

  • Pharmaceutical Science

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    Niidome, T., Yamagata, M., Okamoto, Y., Akiyama, Y., Takahashi, H., Kawano, T., Katayama, Y., & Niidome, Y. (2006). PEG-modified gold nanorods with a stealth character for in vivo applications. Journal of Controlled Release, 114(3), 343-347. https://doi.org/10.1016/j.jconrel.2006.06.017