Pemetrexed combined with platinum-based chemotherapy for advanced malignant peritoneal mesothelioma: Retrospective analysis of six cases

Michitaka Nakano, Hitoshi Kusaba, Akitaka Makiyama, Hiroshi Ariyama, Shuji Arita, Hisanobu Oda, Taito Esaki, Kotoe Takayoshi, Keita Uchino, Shingo Tamura, Hozumi Kumagai, Eiji Iwama, Tsuyoshi Shirakawa, Kenji Mitsugi, Shigeo Takaishi, Koichi Akashi, Eishi Baba

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Abstract

Background: Malignant peritoneal mesothelioma (PM) is an extremely rare disease. Pemetrexed and platinum have been used for advanced PM following malignant pleural mesothelioma (PLM). Because PM differs considerably from PLM in clinical features, the efficacy and safety of these therapies have yet to be established. Patients and Methods: Six Japanese patients with PM who had been treated with pemetrexed-based chemotherapy in four Institutions were retrospectively identified. Treatment response, progression-free survival, and overall survival were examined. Toxicities of therapy were also evaluated. Results: Three patients with mild ascites achieved clinical benefits (one with partial response and two with stable disease). Treatments with reduced cisplatin or carboplatin for patients with massive ascites were safely performed. Median PFS and OS were 7.2 and 13.1 months, respectively. Grade 3 hematological toxicities appeared in two patients with massive ascites. Conclusion: Selection of chemotherapy based on the patient's condition, such as ascites, might be important for advanced PM.

Original languageEnglish
Pages (from-to)215-220
Number of pages6
JournalAnticancer research
Volume34
Issue number1
Publication statusPublished - Jan 1 2014

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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    Nakano, M., Kusaba, H., Makiyama, A., Ariyama, H., Arita, S., Oda, H., Esaki, T., Takayoshi, K., Uchino, K., Tamura, S., Kumagai, H., Iwama, E., Shirakawa, T., Mitsugi, K., Takaishi, S., Akashi, K., & Baba, E. (2014). Pemetrexed combined with platinum-based chemotherapy for advanced malignant peritoneal mesothelioma: Retrospective analysis of six cases. Anticancer research, 34(1), 215-220.