Pemetrexed-induced scleroderma-like conditions in the lower legs of a patient with non-small cell lung carcinoma

Kazushi Ishikawa, Takashi Sakai, Tomoko Saito-Shono, Michiyo Miyawaki, Atsushi Osoegawa, Kenji Sugio, Asami Ono, Hiromu Mori, Haruto Nishida, Shigeo Yokoyama, Osamu Okamoto, Sakuhei Fujiwara, Yutaka Hatano

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Pemetrexed, which is used for the treatment of non-small cell lung carcinoma and malignant mesothelioma, induces cutaneous adverse reactions in approximately 20% of patients. There are also reports of the induction of fibrosing disorders. We describe a case of pemetrexed-induced scleroderma-like conditions in the lower legs of a patient whose pulmonary carcinoma has been relatively well controlled, with prolongation of the dose interval, in spite of the discomfort in both his legs. Skin biopsy revealed dermal fibrosis and dilated lymph vessels in the dermis, but lymphocytic infiltration around the lymph vessels, in contrast to the blood vessels, was minimal. Immunohistochemical staining revealed that the major subsets of T cells that had infiltrated around blood vessels were CD3 and CD45Ro, but no B cells were detected. High serum levels of interleukin (IL)-4 and IL-6 suggested that T cells, which secrete these cytokines, may be involved in the pathogenesis of this condition. Magnetic resonance imaging of the lower extremities revealed muscular and fascial involvement. Several chemotherapeutic agents, such as taxanes, gemcitabine and bleomycin, are known to induce scleroderma-like changes, and we should also keep the side-effects of pemetrexed in mind when we encounter patients with fibrosing conditions.

Original languageEnglish
Pages (from-to)1071-1074
Number of pages4
JournalJournal of Dermatology
Volume43
Issue number9
DOIs
Publication statusPublished - Sep 1 2016
Externally publishedYes

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Pemetrexed
Non-Small Cell Lung Carcinoma
Leg
Lymph
gemcitabine
Skin
Blood Vessels
Taxoids
Bleomycin
T-Lymphocyte Subsets
Dermis
Interleukin-4
Lower Extremity
Interleukin-6
Fibrosis
B-Lymphocytes
Magnetic Resonance Imaging
Staining and Labeling
Cytokines
Carcinoma

All Science Journal Classification (ASJC) codes

  • Dermatology

Cite this

Pemetrexed-induced scleroderma-like conditions in the lower legs of a patient with non-small cell lung carcinoma. / Ishikawa, Kazushi; Sakai, Takashi; Saito-Shono, Tomoko; Miyawaki, Michiyo; Osoegawa, Atsushi; Sugio, Kenji; Ono, Asami; Mori, Hiromu; Nishida, Haruto; Yokoyama, Shigeo; Okamoto, Osamu; Fujiwara, Sakuhei; Hatano, Yutaka.

In: Journal of Dermatology, Vol. 43, No. 9, 01.09.2016, p. 1071-1074.

Research output: Contribution to journalArticle

Ishikawa, K, Sakai, T, Saito-Shono, T, Miyawaki, M, Osoegawa, A, Sugio, K, Ono, A, Mori, H, Nishida, H, Yokoyama, S, Okamoto, O, Fujiwara, S & Hatano, Y 2016, 'Pemetrexed-induced scleroderma-like conditions in the lower legs of a patient with non-small cell lung carcinoma', Journal of Dermatology, vol. 43, no. 9, pp. 1071-1074. https://doi.org/10.1111/1346-8138.13354
Ishikawa, Kazushi ; Sakai, Takashi ; Saito-Shono, Tomoko ; Miyawaki, Michiyo ; Osoegawa, Atsushi ; Sugio, Kenji ; Ono, Asami ; Mori, Hiromu ; Nishida, Haruto ; Yokoyama, Shigeo ; Okamoto, Osamu ; Fujiwara, Sakuhei ; Hatano, Yutaka. / Pemetrexed-induced scleroderma-like conditions in the lower legs of a patient with non-small cell lung carcinoma. In: Journal of Dermatology. 2016 ; Vol. 43, No. 9. pp. 1071-1074.
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