Peptide-Based Switching of Polymer Fluorescence in Aqueous phase

Hirotaka Ejima, Hiromi Kikuchi, Hisao Matsuno, Hirofumi Yajima, Takeshi Serizawa

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)

Abstract

The phage display method on water-soluble and commonly used poly-(2-methoxy-5-propyloxysulfonate-1,4-phenylenevinylene) (mpsPPV) were studied. mpsPPV was immobilized using a layer-by-layer (LbL) assembly technique with poly(diallyldimethylammonium chloride) (PDDA) to obtain water-insoluble polyelectrolyte multilayer films, with an outermost surface composed of mpsPPV, on a glass substrate. The assembly process and the stability of the obtained LbL films were monitored by quartz-crystal microbalance (QCM) measurement. A linear 12-mer peptide library solution was applied to this LbL film. The LbL film was considered to be stable throughout the phage display experiment, because the frequency shift was negligible after immersion in ethanol and Tris-buffered saline. It was suggested that π-π interactions were predominant between the peptide and mpsPPV.

Original languageEnglish
Pages (from-to)6032-6034
Number of pages3
JournalChemistry of Materials
Volume22
Issue number22
DOIs
Publication statusPublished - Nov 23 2010
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Chemical Engineering(all)
  • Materials Chemistry

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